CTLA4 DNA methylation is associated with CTLA-4 expression and predicts response to immunotherapy in head and neck squamous cell carcinoma

BACKGROUND: The majority of patients with recurrent or metastasized head and neck squamous cell carcinoma (HNSCC) do not benefit from immune checkpoint blockade (ICB) while several patients experience severe and persistent immune-mediated side effects. Therefore, predictive biomarkers are urgently n...

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Detalles Bibliográficos
Autores principales: Hoffmann, Friederike, Franzen, Alina, de Vos, Luka, Wuest, Lennert, Kulcsár, Zsófi, Fietz, Simon, Maas, Alexander Philippe, Hollick, Sarah, Diop, Marie Yatou, Gabrielpillai, Jennis, Vogt, Timo, Kuster, Pia, Zarbl, Romina, Dietrich, Joern, Kristiansen, Glen, Brossart, Peter, Landsberg, Jennifer, Strieth, Sebastian, Dietrich, Dimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327338/
https://www.ncbi.nlm.nih.gov/pubmed/37415208
http://dx.doi.org/10.1186/s13148-023-01525-6

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