The impact of ABCB1, CYP3A4/5 and ABCG2 gene polymorphisms on rivaroxaban trough concentrations and bleeding events in patients with non-valvular atrial fibrillation

BACKGROUND: The influence of genetic factors on the pharmacokinetics and clinical outcomes of rivaroxaban in patients with non-valvular atrial fibrillation (NVAF) is poorly understood. This study aimed to explore the effects of CYP3A4/5, ABCB1, and ABCG2 gene polymorphisms on the trough concentratio...

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Detalles Bibliográficos
Autores principales: Wu, Tingting, Wu, Shuyi, Li, Li, Xiang, Jing, Wang, Na, Chen, Wenjun, Zhang, Jinhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327396/
https://www.ncbi.nlm.nih.gov/pubmed/37420302
http://dx.doi.org/10.1186/s40246-023-00506-3

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