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Novel evidence on sepsis-inducing pathogens: from laboratory to bedside
Sepsis is a life-threatening condition and a significant cause of preventable morbidity and mortality globally. Among the leading causative agents of sepsis are bacterial pathogens Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, Pseudomonas aeruginosa, and Streptococcus pyogenes, alo...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327444/ https://www.ncbi.nlm.nih.gov/pubmed/37426029 http://dx.doi.org/10.3389/fmicb.2023.1198200 |
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author | Gatica, Sebastian Fuentes, Brandon Rivera-Asín, Elizabeth Ramírez-Céspedes, Paula Sepúlveda-Alfaro, Javiera Catalán, Eduardo A. Bueno, Susan M. Kalergis, Alexis M. Simon, Felipe Riedel, Claudia A. Melo-Gonzalez, Felipe |
author_facet | Gatica, Sebastian Fuentes, Brandon Rivera-Asín, Elizabeth Ramírez-Céspedes, Paula Sepúlveda-Alfaro, Javiera Catalán, Eduardo A. Bueno, Susan M. Kalergis, Alexis M. Simon, Felipe Riedel, Claudia A. Melo-Gonzalez, Felipe |
author_sort | Gatica, Sebastian |
collection | PubMed |
description | Sepsis is a life-threatening condition and a significant cause of preventable morbidity and mortality globally. Among the leading causative agents of sepsis are bacterial pathogens Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, Pseudomonas aeruginosa, and Streptococcus pyogenes, along with fungal pathogens of the Candida species. Here, we focus on evidence from human studies but also include in vitro and in vivo cellular and molecular evidence, exploring how bacterial and fungal pathogens are associated with bloodstream infection and sepsis. This review presents a narrative update on pathogen epidemiology, virulence factors, host factors of susceptibility, mechanisms of immunomodulation, current therapies, antibiotic resistance, and opportunities for diagnosis, prognosis, and therapeutics, through the perspective of bloodstream infection and sepsis. A list of curated novel host and pathogen factors, diagnostic and prognostic markers, and potential therapeutical targets to tackle sepsis from the research laboratory is presented. Further, we discuss the complex nature of sepsis depending on the sepsis-inducing pathogen and host susceptibility, the more common strains associated with severe pathology and how these aspects may impact in the management of the clinical presentation of sepsis. |
format | Online Article Text |
id | pubmed-10327444 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103274442023-07-08 Novel evidence on sepsis-inducing pathogens: from laboratory to bedside Gatica, Sebastian Fuentes, Brandon Rivera-Asín, Elizabeth Ramírez-Céspedes, Paula Sepúlveda-Alfaro, Javiera Catalán, Eduardo A. Bueno, Susan M. Kalergis, Alexis M. Simon, Felipe Riedel, Claudia A. Melo-Gonzalez, Felipe Front Microbiol Microbiology Sepsis is a life-threatening condition and a significant cause of preventable morbidity and mortality globally. Among the leading causative agents of sepsis are bacterial pathogens Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, Pseudomonas aeruginosa, and Streptococcus pyogenes, along with fungal pathogens of the Candida species. Here, we focus on evidence from human studies but also include in vitro and in vivo cellular and molecular evidence, exploring how bacterial and fungal pathogens are associated with bloodstream infection and sepsis. This review presents a narrative update on pathogen epidemiology, virulence factors, host factors of susceptibility, mechanisms of immunomodulation, current therapies, antibiotic resistance, and opportunities for diagnosis, prognosis, and therapeutics, through the perspective of bloodstream infection and sepsis. A list of curated novel host and pathogen factors, diagnostic and prognostic markers, and potential therapeutical targets to tackle sepsis from the research laboratory is presented. Further, we discuss the complex nature of sepsis depending on the sepsis-inducing pathogen and host susceptibility, the more common strains associated with severe pathology and how these aspects may impact in the management of the clinical presentation of sepsis. Frontiers Media S.A. 2023-06-23 /pmc/articles/PMC10327444/ /pubmed/37426029 http://dx.doi.org/10.3389/fmicb.2023.1198200 Text en Copyright © 2023 Gatica, Fuentes, Rivera-Asín, Ramírez-Céspedes, Sepúlveda-Alfaro, Catalán, Bueno, Kalergis, Simon, Riedel and Melo-Gonzalez. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Gatica, Sebastian Fuentes, Brandon Rivera-Asín, Elizabeth Ramírez-Céspedes, Paula Sepúlveda-Alfaro, Javiera Catalán, Eduardo A. Bueno, Susan M. Kalergis, Alexis M. Simon, Felipe Riedel, Claudia A. Melo-Gonzalez, Felipe Novel evidence on sepsis-inducing pathogens: from laboratory to bedside |
title | Novel evidence on sepsis-inducing pathogens: from laboratory to bedside |
title_full | Novel evidence on sepsis-inducing pathogens: from laboratory to bedside |
title_fullStr | Novel evidence on sepsis-inducing pathogens: from laboratory to bedside |
title_full_unstemmed | Novel evidence on sepsis-inducing pathogens: from laboratory to bedside |
title_short | Novel evidence on sepsis-inducing pathogens: from laboratory to bedside |
title_sort | novel evidence on sepsis-inducing pathogens: from laboratory to bedside |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327444/ https://www.ncbi.nlm.nih.gov/pubmed/37426029 http://dx.doi.org/10.3389/fmicb.2023.1198200 |
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