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A Review of Potential Neuroimaging Biomarkers of Schizophrenia-Risk
The risk for developing schizophrenia is increased among first-degree relatives of those with psychotic disorders, but the risk is even higher in those meeting established criteria for clinical high risk (CHR), a clinical construct most often comprising of attenuated psychotic experiences. Conversio...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327607/ https://www.ncbi.nlm.nih.gov/pubmed/37427077 http://dx.doi.org/10.20900/jpbs.20230005 |
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author | Mamah, Daniel |
author_facet | Mamah, Daniel |
author_sort | Mamah, Daniel |
collection | PubMed |
description | The risk for developing schizophrenia is increased among first-degree relatives of those with psychotic disorders, but the risk is even higher in those meeting established criteria for clinical high risk (CHR), a clinical construct most often comprising of attenuated psychotic experiences. Conversion to psychosis among CHR youth has been reported to be about 15–35% over three years. Accurately identifying individuals whose psychotic symptoms will worsen would facilitate earlier intervention, but this has been difficult to do using behavior measures alone. Brain-based risk markers have the potential to improve the accuracy of predicting outcomes in CHR youth. This narrative review provides an overview of neuroimaging studies used to investigate psychosis risk, including studies involving structural, functional, and diffusion imaging, functional connectivity, positron emission tomography, arterial spin labeling, magnetic resonance spectroscopy, and multi-modality approaches. We present findings separately in those observed in the CHR state and those associated with psychosis progression or resilience. Finally, we discuss future research directions that could improve clinical care for those at high risk for developing psychotic disorders. |
format | Online Article Text |
id | pubmed-10327607 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
record_format | MEDLINE/PubMed |
spelling | pubmed-103276072023-07-07 A Review of Potential Neuroimaging Biomarkers of Schizophrenia-Risk Mamah, Daniel J Psychiatr Brain Sci Article The risk for developing schizophrenia is increased among first-degree relatives of those with psychotic disorders, but the risk is even higher in those meeting established criteria for clinical high risk (CHR), a clinical construct most often comprising of attenuated psychotic experiences. Conversion to psychosis among CHR youth has been reported to be about 15–35% over three years. Accurately identifying individuals whose psychotic symptoms will worsen would facilitate earlier intervention, but this has been difficult to do using behavior measures alone. Brain-based risk markers have the potential to improve the accuracy of predicting outcomes in CHR youth. This narrative review provides an overview of neuroimaging studies used to investigate psychosis risk, including studies involving structural, functional, and diffusion imaging, functional connectivity, positron emission tomography, arterial spin labeling, magnetic resonance spectroscopy, and multi-modality approaches. We present findings separately in those observed in the CHR state and those associated with psychosis progression or resilience. Finally, we discuss future research directions that could improve clinical care for those at high risk for developing psychotic disorders. 2023 2023-05-26 /pmc/articles/PMC10327607/ /pubmed/37427077 http://dx.doi.org/10.20900/jpbs.20230005 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms and conditions of Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Mamah, Daniel A Review of Potential Neuroimaging Biomarkers of Schizophrenia-Risk |
title | A Review of Potential Neuroimaging Biomarkers of Schizophrenia-Risk |
title_full | A Review of Potential Neuroimaging Biomarkers of Schizophrenia-Risk |
title_fullStr | A Review of Potential Neuroimaging Biomarkers of Schizophrenia-Risk |
title_full_unstemmed | A Review of Potential Neuroimaging Biomarkers of Schizophrenia-Risk |
title_short | A Review of Potential Neuroimaging Biomarkers of Schizophrenia-Risk |
title_sort | review of potential neuroimaging biomarkers of schizophrenia-risk |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327607/ https://www.ncbi.nlm.nih.gov/pubmed/37427077 http://dx.doi.org/10.20900/jpbs.20230005 |
work_keys_str_mv | AT mamahdaniel areviewofpotentialneuroimagingbiomarkersofschizophreniarisk AT mamahdaniel reviewofpotentialneuroimagingbiomarkersofschizophreniarisk |