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Association between Body Mass Index and Mortality in Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis

BACKGROUND: The association between body mass index (BMI) and mortality in patients with type 1 diabetes mellitus (T1DM) has been poorly examined and has never been systematically reviewed. This meta-analysis investigated the all-cause mortality risk for each BMI category among patients with T1DM. M...

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Autores principales: Jung, Han Na, Kim, Sehee, Jung, Chang Hee, Cho, Yun Kyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for the Study of Obesity 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327680/
https://www.ncbi.nlm.nih.gov/pubmed/37280725
http://dx.doi.org/10.7570/jomes22061
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author Jung, Han Na
Kim, Sehee
Jung, Chang Hee
Cho, Yun Kyung
author_facet Jung, Han Na
Kim, Sehee
Jung, Chang Hee
Cho, Yun Kyung
author_sort Jung, Han Na
collection PubMed
description BACKGROUND: The association between body mass index (BMI) and mortality in patients with type 1 diabetes mellitus (T1DM) has been poorly examined and has never been systematically reviewed. This meta-analysis investigated the all-cause mortality risk for each BMI category among patients with T1DM. METHODS: A systematic literature review of the PubMed, Embase, and Cochrane Library databases was performed in July 2022. Cohort studies comparing the mortality risk between BMI categories among patients with T1DM were eligible. Pooled hazard ratios (HRs) for all-cause mortality among underweight (BMI <18.5 kg/m(2)), overweight (BMI, 25 to <30 kg/m(2)), and obese (BMI ≥30 kg/m(2)) individuals were calculated in reference to the normal-weight group (BMI, 18.5 to <25 kg/m(2)). The Newcastle-Ottawa Scale was used to assess the risk of bias. RESULTS: Three prospective studies involving 23,407 adults were included. The underweight group was shown to have a 3.4 times greater risk of mortality than the normal-weight group (95% confidence interval [CI], 1.67 to 6.85). Meanwhile, there was no significant difference in mortality risk between the normal-weight group and the overweight group (HR, 0.90; 95% CI, 0.66 to 1.22) or the obese group (HR, 1.36; 95% CI, 0.86 to 2.15), possibly due to the heterogeneous results of these BMI categories among the included studies. CONCLUSION: Underweight patients with T1DM had a significantly greater risk of all-cause mortality than their normal-weight counterparts. Overweight and obese patients showed heterogeneous risks across the studies. Further prospective studies on patients with T1DM are required to establish weight management guidelines.
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spelling pubmed-103276802023-07-08 Association between Body Mass Index and Mortality in Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis Jung, Han Na Kim, Sehee Jung, Chang Hee Cho, Yun Kyung J Obes Metab Syndr Original Article BACKGROUND: The association between body mass index (BMI) and mortality in patients with type 1 diabetes mellitus (T1DM) has been poorly examined and has never been systematically reviewed. This meta-analysis investigated the all-cause mortality risk for each BMI category among patients with T1DM. METHODS: A systematic literature review of the PubMed, Embase, and Cochrane Library databases was performed in July 2022. Cohort studies comparing the mortality risk between BMI categories among patients with T1DM were eligible. Pooled hazard ratios (HRs) for all-cause mortality among underweight (BMI <18.5 kg/m(2)), overweight (BMI, 25 to <30 kg/m(2)), and obese (BMI ≥30 kg/m(2)) individuals were calculated in reference to the normal-weight group (BMI, 18.5 to <25 kg/m(2)). The Newcastle-Ottawa Scale was used to assess the risk of bias. RESULTS: Three prospective studies involving 23,407 adults were included. The underweight group was shown to have a 3.4 times greater risk of mortality than the normal-weight group (95% confidence interval [CI], 1.67 to 6.85). Meanwhile, there was no significant difference in mortality risk between the normal-weight group and the overweight group (HR, 0.90; 95% CI, 0.66 to 1.22) or the obese group (HR, 1.36; 95% CI, 0.86 to 2.15), possibly due to the heterogeneous results of these BMI categories among the included studies. CONCLUSION: Underweight patients with T1DM had a significantly greater risk of all-cause mortality than their normal-weight counterparts. Overweight and obese patients showed heterogeneous risks across the studies. Further prospective studies on patients with T1DM are required to establish weight management guidelines. Korean Society for the Study of Obesity 2023-06-30 2023-06-07 /pmc/articles/PMC10327680/ /pubmed/37280725 http://dx.doi.org/10.7570/jomes22061 Text en Copyright © 2023 Korean Society for the Study of Obesity https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Jung, Han Na
Kim, Sehee
Jung, Chang Hee
Cho, Yun Kyung
Association between Body Mass Index and Mortality in Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis
title Association between Body Mass Index and Mortality in Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis
title_full Association between Body Mass Index and Mortality in Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis
title_fullStr Association between Body Mass Index and Mortality in Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis
title_full_unstemmed Association between Body Mass Index and Mortality in Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis
title_short Association between Body Mass Index and Mortality in Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis
title_sort association between body mass index and mortality in type 1 diabetes mellitus: a systematic review and meta-analysis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327680/
https://www.ncbi.nlm.nih.gov/pubmed/37280725
http://dx.doi.org/10.7570/jomes22061
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