Cargando…

Transiently impaired endothelial function during thyroid hormone withdrawal in differentiated thyroid cancer patients

PURPOSE: Endothelial dysfunction, which was associated with chronic hypothyroidism, was an early event in atherosclerosis. Whether short-term hypothyroidism following thyroxine withdrawal during radioiodine (RAI) therapy was associated with endothelial dysfunction in patients with differentiated thy...

Descripción completa

Detalles Bibliográficos
Autores principales: Hou, Li-ying, Li, Xiao, Zhang, Guo-qiang, Xi, Chuang, Shen, Chen-tian, Song, Hong-jun, Bai, Wen-kun, Qiu, Zhong-ling, Luo, Quan-yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327818/
https://www.ncbi.nlm.nih.gov/pubmed/37424871
http://dx.doi.org/10.3389/fendo.2023.1164789
_version_ 1785069682885132288
author Hou, Li-ying
Li, Xiao
Zhang, Guo-qiang
Xi, Chuang
Shen, Chen-tian
Song, Hong-jun
Bai, Wen-kun
Qiu, Zhong-ling
Luo, Quan-yong
author_facet Hou, Li-ying
Li, Xiao
Zhang, Guo-qiang
Xi, Chuang
Shen, Chen-tian
Song, Hong-jun
Bai, Wen-kun
Qiu, Zhong-ling
Luo, Quan-yong
author_sort Hou, Li-ying
collection PubMed
description PURPOSE: Endothelial dysfunction, which was associated with chronic hypothyroidism, was an early event in atherosclerosis. Whether short-term hypothyroidism following thyroxine withdrawal during radioiodine (RAI) therapy was associated with endothelial dysfunction in patients with differentiated thyroid cancer (DTC) was unclear. Aim of the study was to assess whether short-term hypothyroidism could impair endothelial function and the accompanied metabolic changes in the whole process of RAI therapy. METHODS: We recruited fifty-one patients who underwent total thyroidectomy surgery and would accept RAI therapy for DTC. We analyzed thyroid function, endothelial function and serum lipids levels of the patients at three time points: the day before thyroxine withdrawal(P(1)), the day before (131)I administration(P(2)) and 4-6 weeks after RAI therapy(P(3)). A high-resolution ultrasound named flow-mediated dilation (FMD) was used to measure endothelial function of the patients. RESULTS: We analyzed the changes of FMD, thyroid function and lipids at three time points. FMD(P(2)) decreased significantly compared to FMD(P(1)) (P(1)vsP(2), 8.05 ± 1.55vs 7.26 ± 1.50, p<0.001). There was no significant difference between FMD(P(3)) and FMD(P(1)) after restoring TSH (thyroid stimulating hormone) suppression therapy (P(1) vs P3, 8.05 ± 1.55 vs 7.79 ± 1.38, p=0.146). Among all parameters, the change of low-density lipoprotein (ΔLDL) was the only factor correlated negatively with the change of FMD (ΔFMD) throughout the RAI therapy process (P(1-2), r=-0.326, p=0.020; P(2-3), r=-0.306, p=0.029). CONCLUSION: Endothelial function was transiently impaired in DTC patients at short-term hypothyroidism state during the RAI therapy, and immediately returned to the initial state after restoring TSH suppression therapy.
format Online
Article
Text
id pubmed-10327818
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-103278182023-07-08 Transiently impaired endothelial function during thyroid hormone withdrawal in differentiated thyroid cancer patients Hou, Li-ying Li, Xiao Zhang, Guo-qiang Xi, Chuang Shen, Chen-tian Song, Hong-jun Bai, Wen-kun Qiu, Zhong-ling Luo, Quan-yong Front Endocrinol (Lausanne) Endocrinology PURPOSE: Endothelial dysfunction, which was associated with chronic hypothyroidism, was an early event in atherosclerosis. Whether short-term hypothyroidism following thyroxine withdrawal during radioiodine (RAI) therapy was associated with endothelial dysfunction in patients with differentiated thyroid cancer (DTC) was unclear. Aim of the study was to assess whether short-term hypothyroidism could impair endothelial function and the accompanied metabolic changes in the whole process of RAI therapy. METHODS: We recruited fifty-one patients who underwent total thyroidectomy surgery and would accept RAI therapy for DTC. We analyzed thyroid function, endothelial function and serum lipids levels of the patients at three time points: the day before thyroxine withdrawal(P(1)), the day before (131)I administration(P(2)) and 4-6 weeks after RAI therapy(P(3)). A high-resolution ultrasound named flow-mediated dilation (FMD) was used to measure endothelial function of the patients. RESULTS: We analyzed the changes of FMD, thyroid function and lipids at three time points. FMD(P(2)) decreased significantly compared to FMD(P(1)) (P(1)vsP(2), 8.05 ± 1.55vs 7.26 ± 1.50, p<0.001). There was no significant difference between FMD(P(3)) and FMD(P(1)) after restoring TSH (thyroid stimulating hormone) suppression therapy (P(1) vs P3, 8.05 ± 1.55 vs 7.79 ± 1.38, p=0.146). Among all parameters, the change of low-density lipoprotein (ΔLDL) was the only factor correlated negatively with the change of FMD (ΔFMD) throughout the RAI therapy process (P(1-2), r=-0.326, p=0.020; P(2-3), r=-0.306, p=0.029). CONCLUSION: Endothelial function was transiently impaired in DTC patients at short-term hypothyroidism state during the RAI therapy, and immediately returned to the initial state after restoring TSH suppression therapy. Frontiers Media S.A. 2023-06-22 /pmc/articles/PMC10327818/ /pubmed/37424871 http://dx.doi.org/10.3389/fendo.2023.1164789 Text en Copyright © 2023 Hou, Li, Zhang, Xi, Shen, Song, Bai, Qiu and Luo https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Hou, Li-ying
Li, Xiao
Zhang, Guo-qiang
Xi, Chuang
Shen, Chen-tian
Song, Hong-jun
Bai, Wen-kun
Qiu, Zhong-ling
Luo, Quan-yong
Transiently impaired endothelial function during thyroid hormone withdrawal in differentiated thyroid cancer patients
title Transiently impaired endothelial function during thyroid hormone withdrawal in differentiated thyroid cancer patients
title_full Transiently impaired endothelial function during thyroid hormone withdrawal in differentiated thyroid cancer patients
title_fullStr Transiently impaired endothelial function during thyroid hormone withdrawal in differentiated thyroid cancer patients
title_full_unstemmed Transiently impaired endothelial function during thyroid hormone withdrawal in differentiated thyroid cancer patients
title_short Transiently impaired endothelial function during thyroid hormone withdrawal in differentiated thyroid cancer patients
title_sort transiently impaired endothelial function during thyroid hormone withdrawal in differentiated thyroid cancer patients
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327818/
https://www.ncbi.nlm.nih.gov/pubmed/37424871
http://dx.doi.org/10.3389/fendo.2023.1164789
work_keys_str_mv AT houliying transientlyimpairedendothelialfunctionduringthyroidhormonewithdrawalindifferentiatedthyroidcancerpatients
AT lixiao transientlyimpairedendothelialfunctionduringthyroidhormonewithdrawalindifferentiatedthyroidcancerpatients
AT zhangguoqiang transientlyimpairedendothelialfunctionduringthyroidhormonewithdrawalindifferentiatedthyroidcancerpatients
AT xichuang transientlyimpairedendothelialfunctionduringthyroidhormonewithdrawalindifferentiatedthyroidcancerpatients
AT shenchentian transientlyimpairedendothelialfunctionduringthyroidhormonewithdrawalindifferentiatedthyroidcancerpatients
AT songhongjun transientlyimpairedendothelialfunctionduringthyroidhormonewithdrawalindifferentiatedthyroidcancerpatients
AT baiwenkun transientlyimpairedendothelialfunctionduringthyroidhormonewithdrawalindifferentiatedthyroidcancerpatients
AT qiuzhongling transientlyimpairedendothelialfunctionduringthyroidhormonewithdrawalindifferentiatedthyroidcancerpatients
AT luoquanyong transientlyimpairedendothelialfunctionduringthyroidhormonewithdrawalindifferentiatedthyroidcancerpatients