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Correlations between the alpha-Gal antigen, antibody response and calcification of cardiac valve bioprostheses: experimental evidence obtained using an alpha-Gal knockout mouse animal model

INTRODUCTION: Preformed antibodies against αGal in the human and the presence of αGal antigens on the tissue constituting the commercial bioprosthetic heart valves (BHVs, mainly bovine or porcine pericardium), lead to opsonization of the implanted BHV, leading to deterioration and calcification. Mur...

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Detalles Bibliográficos
Autores principales:	Naso, Filippo, Colli, Andrea, Zilla, Peter, Calafiore, Antonio Maria, Lotan, Chaim, Padalino, Massimo A., Sturaro, Giulio, Gandaglia, Alessandro, Spina, Michele
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327888/ https://www.ncbi.nlm.nih.gov/pubmed/37426661 http://dx.doi.org/10.3389/fimmu.2023.1210098

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