Reduced binding of apoE4 to complement factor H promotes amyloid‐β oligomerization and neuroinflammation

The APOE4 variant of apolipoprotein E (apoE) is the most prevalent genetic risk allele associated with late‐onset Alzheimer's disease (AD). ApoE interacts with complement regulator factor H (FH), but the role of this interaction in AD pathogenesis is unknown. Here we elucidate the mechanism by...

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Detalles Bibliográficos
Autores principales: Chernyaeva, Larisa, Ratti, Giorgio, Teirilä, Laura, Fudo, Satoshi, Rankka, Uni, Pelkonen, Anssi, Korhonen, Paula, Leskinen, Katarzyna, Keskitalo, Salla, Salokas, Kari, Gkolfinopoulou, Christina, Crompton, Katrina E, Javanainen, Matti, Happonen, Lotta, Varjosalo, Markku, Malm, Tarja, Leinonen, Ville, Chroni, Angeliki, Saavalainen, Päivi, Meri, Seppo, Kajander, Tommi, Wollman, Adam JM, Nissilä, Eija, Haapasalo, Karita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10328077/
https://www.ncbi.nlm.nih.gov/pubmed/37155564
http://dx.doi.org/10.15252/embr.202256467

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