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Bacteria‐instructed B cells cross‐prime naïve CD8 (+) T cells triggering effective cytotoxic responses
In addition to triggering humoral responses, conventional B cells have been described in vitro to cross‐present exogenous antigens activating naïve CD8(+) T cells. Nevertheless, the way B cells capture these exogenous antigens and the physiological roles of B cell‐mediated cross‐presentation remain...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10328081/ https://www.ncbi.nlm.nih.gov/pubmed/37184882 http://dx.doi.org/10.15252/embr.202256131 |
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author | García‐Ferreras, Raquel Osuna‐Pérez, Jesús Ramírez‐Santiago, Guillermo Méndez‐Pérez, Almudena Acosta‐Moreno, Andrés M Del Campo, Lara Gómez‐Sánchez, María J Iborra, Marta Herrero‐Fernández, Beatriz González‐Granado, José M Sánchez‐Madrid, Francisco Carrasco, Yolanda R Boya, Patricia Martínez‐Martín, Nuria Veiga, Esteban |
author_facet | García‐Ferreras, Raquel Osuna‐Pérez, Jesús Ramírez‐Santiago, Guillermo Méndez‐Pérez, Almudena Acosta‐Moreno, Andrés M Del Campo, Lara Gómez‐Sánchez, María J Iborra, Marta Herrero‐Fernández, Beatriz González‐Granado, José M Sánchez‐Madrid, Francisco Carrasco, Yolanda R Boya, Patricia Martínez‐Martín, Nuria Veiga, Esteban |
author_sort | García‐Ferreras, Raquel |
collection | PubMed |
description | In addition to triggering humoral responses, conventional B cells have been described in vitro to cross‐present exogenous antigens activating naïve CD8(+) T cells. Nevertheless, the way B cells capture these exogenous antigens and the physiological roles of B cell‐mediated cross‐presentation remain poorly explored. Here, we show that B cells capture bacteria by trans‐phagocytosis from previously infected dendritic cells (DC) when they are in close contact. Bacterial encounter “instructs” the B cells to acquire antigen cross‐presentation abilities, in a process that involves autophagy. Bacteria‐instructed B cells, henceforth referred to as BacB cells, rapidly degrade phagocytosed bacteria, process bacterial antigens and cross‐prime naïve CD8(+) T cells which differentiate into specific cytotoxic cells that efficiently control bacterial infections. Moreover, a proof‐of‐concept experiment shows that BacB cells that have captured bacteria expressing tumor antigens could be useful as novel cellular immunotherapies against cancer. |
format | Online Article Text |
id | pubmed-10328081 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103280812023-07-08 Bacteria‐instructed B cells cross‐prime naïve CD8 (+) T cells triggering effective cytotoxic responses García‐Ferreras, Raquel Osuna‐Pérez, Jesús Ramírez‐Santiago, Guillermo Méndez‐Pérez, Almudena Acosta‐Moreno, Andrés M Del Campo, Lara Gómez‐Sánchez, María J Iborra, Marta Herrero‐Fernández, Beatriz González‐Granado, José M Sánchez‐Madrid, Francisco Carrasco, Yolanda R Boya, Patricia Martínez‐Martín, Nuria Veiga, Esteban EMBO Rep Articles In addition to triggering humoral responses, conventional B cells have been described in vitro to cross‐present exogenous antigens activating naïve CD8(+) T cells. Nevertheless, the way B cells capture these exogenous antigens and the physiological roles of B cell‐mediated cross‐presentation remain poorly explored. Here, we show that B cells capture bacteria by trans‐phagocytosis from previously infected dendritic cells (DC) when they are in close contact. Bacterial encounter “instructs” the B cells to acquire antigen cross‐presentation abilities, in a process that involves autophagy. Bacteria‐instructed B cells, henceforth referred to as BacB cells, rapidly degrade phagocytosed bacteria, process bacterial antigens and cross‐prime naïve CD8(+) T cells which differentiate into specific cytotoxic cells that efficiently control bacterial infections. Moreover, a proof‐of‐concept experiment shows that BacB cells that have captured bacteria expressing tumor antigens could be useful as novel cellular immunotherapies against cancer. John Wiley and Sons Inc. 2023-05-15 /pmc/articles/PMC10328081/ /pubmed/37184882 http://dx.doi.org/10.15252/embr.202256131 Text en © 2023 The Authors. Published under the terms of the CC BY NC ND 4.0 license. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Articles García‐Ferreras, Raquel Osuna‐Pérez, Jesús Ramírez‐Santiago, Guillermo Méndez‐Pérez, Almudena Acosta‐Moreno, Andrés M Del Campo, Lara Gómez‐Sánchez, María J Iborra, Marta Herrero‐Fernández, Beatriz González‐Granado, José M Sánchez‐Madrid, Francisco Carrasco, Yolanda R Boya, Patricia Martínez‐Martín, Nuria Veiga, Esteban Bacteria‐instructed B cells cross‐prime naïve CD8 (+) T cells triggering effective cytotoxic responses |
title | Bacteria‐instructed B cells cross‐prime naïve CD8
(+) T cells triggering effective cytotoxic responses |
title_full | Bacteria‐instructed B cells cross‐prime naïve CD8
(+) T cells triggering effective cytotoxic responses |
title_fullStr | Bacteria‐instructed B cells cross‐prime naïve CD8
(+) T cells triggering effective cytotoxic responses |
title_full_unstemmed | Bacteria‐instructed B cells cross‐prime naïve CD8
(+) T cells triggering effective cytotoxic responses |
title_short | Bacteria‐instructed B cells cross‐prime naïve CD8
(+) T cells triggering effective cytotoxic responses |
title_sort | bacteria‐instructed b cells cross‐prime naïve cd8
(+) t cells triggering effective cytotoxic responses |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10328081/ https://www.ncbi.nlm.nih.gov/pubmed/37184882 http://dx.doi.org/10.15252/embr.202256131 |
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