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The chloride antiporter CLCN7 is a modifier of lysosome dysfunction in FIG4 and VAC14 mutants
The phosphatase FIG4 and the scaffold protein VAC14 function in the biosynthesis of PI(3,5)P(2), a signaling lipid that inhibits the lysosomal chloride transporter ClC-7. Loss-of-function mutations of FIG4 and VAC14 reduce PI(3,5)P(2) and result in lysosomal disorders characterized by accumulation o...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10328317/ https://www.ncbi.nlm.nih.gov/pubmed/37363915 http://dx.doi.org/10.1371/journal.pgen.1010800 |