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Mechanical manipulation of cancer cell tumorigenicity via heat shock protein signaling

Biophysical cues of rigid tumor matrix play a critical role in cancer cell malignancy. We report that stiffly confined cancer cells exhibit robust growth of spheroids in the stiff hydrogel that exerts substantial confining stress on the cells. The stressed condition activated Hsp (heat shock protein...

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Detalles Bibliográficos
Autores principales:	Wong, Siu Hong Dexter, Yin, Bohan, Li, Zhuo, Yuan, Weihao, Zhang, Qin, Xie, Xian, Tan, Youhua, Wong, Nathalie, Zhang, Kunyu, Bian, Liming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2023
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10328411/ https://www.ncbi.nlm.nih.gov/pubmed/37418519 http://dx.doi.org/10.1126/sciadv.adg9593

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