Single-cell and spatial transcriptomics identify a macrophage population associated with skeletal muscle fibrosis

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Macrophages are essential for skeletal muscle homeostasis, but how their dysregulation contributes to the development of fibrosis in muscle disease remains unclear. Here, we used single-cell transcriptomics to determine the molecular attributes of dystrophic and healthy muscle macrophages. We identi...

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Detalles Bibliográficos
Autores principales: Coulis, Gerald, Jaime, Diego, Guerrero-Juarez, Christian, Kastenschmidt, Jenna M., Farahat, Philip K., Nguyen, Quy, Pervolarakis, Nicholas, McLinden, Katherine, Thurlow, Lauren, Movahedi, Saba, Hughes, Brandon S., Duarte, Jorge, Sorn, Andrew, Montoya, Elizabeth, Mozaffar, Izza, Dragan, Morgan, Othy, Shivashankar, Joshi, Trupti, Hans, Chetan P., Kimonis, Virginia, MacLean, Adam L., Nie, Qing, Wallace, Lindsay M., Harper, Scott Q., Mozaffar, Tahseen, Hogarth, Marshall W., Bhattacharya, Surajit, Jaiswal, Jyoti K., Golann, David R., Su, Qi, Kessenbrock, Kai, Stec, Michael, Spencer, Melissa J., Zamudio, Jesse R., Villalta, S. Armando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10328414/
https://www.ncbi.nlm.nih.gov/pubmed/37418531
http://dx.doi.org/10.1126/sciadv.add9984
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