Mechanistic insights into robust cardiac I(Ks) potassium channel activation by aromatic polyunsaturated fatty acid analogues

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Voltage-gated potassium (K(V)) channels are important regulators of cellular excitability and control action potential repolarization in the heart and brain. K(V) channel mutations lead to disordered cellular excitability. Loss-of-function mutations, for example, result in membrane hyperexcitability...

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Detalles Bibliográficos
Autores principales: Bohannon, Briana M, Jowais, Jessica J, Nyberg, Leif, Olivier-Meo, Vanessa, Corradi, Valentina, Tieleman, D Peter, Liin, Sara I, Larsson, H Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10328494/
https://www.ncbi.nlm.nih.gov/pubmed/37350568
http://dx.doi.org/10.7554/eLife.85773
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