No association between use of tenofovir disoproxil fumarate, etravirine, or integrase-strand transfer inhibitors and acquisition or severe outcomes of SARS-CoV-2 infection in people with HIV in the Netherlands

In two Dutch observational cohorts of people with HIV, the use of TDF, ETR, or INSTIs was not independently associated with either the risk of incident SARS-CoV-2 infection or severe COVID-19 outcomes, as was suggested by previous observational and molecular docking studies. Our findings do not supp...

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Autores principales: Verburgh, Myrthe L., van der Valk, Marc, Rijnders, Bart J.A., Reiss, Peter, Wit, Ferdinand W.N.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Research Letters
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10328501/
https://www.ncbi.nlm.nih.gov/pubmed/37395254
http://dx.doi.org/10.1097/QAD.0000000000003577
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author Verburgh, Myrthe L.
van der Valk, Marc
Rijnders, Bart J.A.
Reiss, Peter
Wit, Ferdinand W.N.M.
author_facet Verburgh, Myrthe L.
van der Valk, Marc
Rijnders, Bart J.A.
Reiss, Peter
Wit, Ferdinand W.N.M.
author_sort Verburgh, Myrthe L.
collection PubMed
description In two Dutch observational cohorts of people with HIV, the use of TDF, ETR, or INSTIs was not independently associated with either the risk of incident SARS-CoV-2 infection or severe COVID-19 outcomes, as was suggested by previous observational and molecular docking studies. Our findings do not support a strategy of modifying antiretroviral therapy to include these agents to protect against SARS-CoV-2 infection and severe COVID-19 outcomes.
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spelling pubmed-103285012023-07-08 No association between use of tenofovir disoproxil fumarate, etravirine, or integrase-strand transfer inhibitors and acquisition or severe outcomes of SARS-CoV-2 infection in people with HIV in the Netherlands Verburgh, Myrthe L. van der Valk, Marc Rijnders, Bart J.A. Reiss, Peter Wit, Ferdinand W.N.M. AIDS Research Letters In two Dutch observational cohorts of people with HIV, the use of TDF, ETR, or INSTIs was not independently associated with either the risk of incident SARS-CoV-2 infection or severe COVID-19 outcomes, as was suggested by previous observational and molecular docking studies. Our findings do not support a strategy of modifying antiretroviral therapy to include these agents to protect against SARS-CoV-2 infection and severe COVID-19 outcomes. Lippincott Williams & Wilkins 2023-07-15 2023-04-13 /pmc/articles/PMC10328501/ /pubmed/37395254 http://dx.doi.org/10.1097/QAD.0000000000003577 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Research Letters
Verburgh, Myrthe L.
van der Valk, Marc
Rijnders, Bart J.A.
Reiss, Peter
Wit, Ferdinand W.N.M.
No association between use of tenofovir disoproxil fumarate, etravirine, or integrase-strand transfer inhibitors and acquisition or severe outcomes of SARS-CoV-2 infection in people with HIV in the Netherlands
title No association between use of tenofovir disoproxil fumarate, etravirine, or integrase-strand transfer inhibitors and acquisition or severe outcomes of SARS-CoV-2 infection in people with HIV in the Netherlands
title_full No association between use of tenofovir disoproxil fumarate, etravirine, or integrase-strand transfer inhibitors and acquisition or severe outcomes of SARS-CoV-2 infection in people with HIV in the Netherlands
title_fullStr No association between use of tenofovir disoproxil fumarate, etravirine, or integrase-strand transfer inhibitors and acquisition or severe outcomes of SARS-CoV-2 infection in people with HIV in the Netherlands
title_full_unstemmed No association between use of tenofovir disoproxil fumarate, etravirine, or integrase-strand transfer inhibitors and acquisition or severe outcomes of SARS-CoV-2 infection in people with HIV in the Netherlands
title_short No association between use of tenofovir disoproxil fumarate, etravirine, or integrase-strand transfer inhibitors and acquisition or severe outcomes of SARS-CoV-2 infection in people with HIV in the Netherlands
title_sort no association between use of tenofovir disoproxil fumarate, etravirine, or integrase-strand transfer inhibitors and acquisition or severe outcomes of sars-cov-2 infection in people with hiv in the netherlands
topic Research Letters
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10328501/
https://www.ncbi.nlm.nih.gov/pubmed/37395254
http://dx.doi.org/10.1097/QAD.0000000000003577
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