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The locus coeruleus broadcasts prediction errors across the cortex to promote sensorimotor plasticity

Prediction errors are differences between expected and actual sensory input and are thought to be key computational signals that drive learning related plasticity. One way that prediction errors could drive learning is by activating neuromodulatory systems to gate plasticity. The catecholaminergic l...

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Autores principales: Jordan, Rebecca, Keller, Georg B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10328511/
https://www.ncbi.nlm.nih.gov/pubmed/37285281
http://dx.doi.org/10.7554/eLife.85111
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author Jordan, Rebecca
Keller, Georg B
author_facet Jordan, Rebecca
Keller, Georg B
author_sort Jordan, Rebecca
collection PubMed
description Prediction errors are differences between expected and actual sensory input and are thought to be key computational signals that drive learning related plasticity. One way that prediction errors could drive learning is by activating neuromodulatory systems to gate plasticity. The catecholaminergic locus coeruleus (LC) is a major neuromodulatory system involved in neuronal plasticity in the cortex. Using two-photon calcium imaging in mice exploring a virtual environment, we found that the activity of LC axons in the cortex correlated with the magnitude of unsigned visuomotor prediction errors. LC response profiles were similar in both motor and visual cortical areas, indicating that LC axons broadcast prediction errors throughout the dorsal cortex. While imaging calcium activity in layer 2/3 of the primary visual cortex, we found that optogenetic stimulation of LC axons facilitated learning of a stimulus-specific suppression of visual responses during locomotion. This plasticity – induced by minutes of LC stimulation – recapitulated the effect of visuomotor learning on a scale that is normally observed during visuomotor development across days. We conclude that prediction errors drive LC activity, and that LC activity facilitates sensorimotor plasticity in the cortex, consistent with a role in modulating learning rates.
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spelling pubmed-103285112023-07-08 The locus coeruleus broadcasts prediction errors across the cortex to promote sensorimotor plasticity Jordan, Rebecca Keller, Georg B eLife Neuroscience Prediction errors are differences between expected and actual sensory input and are thought to be key computational signals that drive learning related plasticity. One way that prediction errors could drive learning is by activating neuromodulatory systems to gate plasticity. The catecholaminergic locus coeruleus (LC) is a major neuromodulatory system involved in neuronal plasticity in the cortex. Using two-photon calcium imaging in mice exploring a virtual environment, we found that the activity of LC axons in the cortex correlated with the magnitude of unsigned visuomotor prediction errors. LC response profiles were similar in both motor and visual cortical areas, indicating that LC axons broadcast prediction errors throughout the dorsal cortex. While imaging calcium activity in layer 2/3 of the primary visual cortex, we found that optogenetic stimulation of LC axons facilitated learning of a stimulus-specific suppression of visual responses during locomotion. This plasticity – induced by minutes of LC stimulation – recapitulated the effect of visuomotor learning on a scale that is normally observed during visuomotor development across days. We conclude that prediction errors drive LC activity, and that LC activity facilitates sensorimotor plasticity in the cortex, consistent with a role in modulating learning rates. eLife Sciences Publications, Ltd 2023-06-07 /pmc/articles/PMC10328511/ /pubmed/37285281 http://dx.doi.org/10.7554/eLife.85111 Text en © 2023, Jordan and Keller https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Jordan, Rebecca
Keller, Georg B
The locus coeruleus broadcasts prediction errors across the cortex to promote sensorimotor plasticity
title The locus coeruleus broadcasts prediction errors across the cortex to promote sensorimotor plasticity
title_full The locus coeruleus broadcasts prediction errors across the cortex to promote sensorimotor plasticity
title_fullStr The locus coeruleus broadcasts prediction errors across the cortex to promote sensorimotor plasticity
title_full_unstemmed The locus coeruleus broadcasts prediction errors across the cortex to promote sensorimotor plasticity
title_short The locus coeruleus broadcasts prediction errors across the cortex to promote sensorimotor plasticity
title_sort locus coeruleus broadcasts prediction errors across the cortex to promote sensorimotor plasticity
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10328511/
https://www.ncbi.nlm.nih.gov/pubmed/37285281
http://dx.doi.org/10.7554/eLife.85111
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