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Death, reoperation, and late cardiopulmonary function after truncus repair
OBJECTIVE: To identify the late surgical outcomes of truncus arteriosus. METHODS: Fifty consecutive patients with truncus arteriosus who underwent surgery between 1978 and 2020 at our institute were enrolled in this retrospective, single institutional cohort study. The primary outcome was death and...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10328806/ https://www.ncbi.nlm.nih.gov/pubmed/37425460 http://dx.doi.org/10.1016/j.xjon.2023.02.010 |
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author | Hoashi, Takaya Imai, Kenta Okuda, Naoki Komori, Motoki Ono, Yoshikazu Kurosaki, Kenichi Ichikawa, Hajime |
author_facet | Hoashi, Takaya Imai, Kenta Okuda, Naoki Komori, Motoki Ono, Yoshikazu Kurosaki, Kenichi Ichikawa, Hajime |
author_sort | Hoashi, Takaya |
collection | PubMed |
description | OBJECTIVE: To identify the late surgical outcomes of truncus arteriosus. METHODS: Fifty consecutive patients with truncus arteriosus who underwent surgery between 1978 and 2020 at our institute were enrolled in this retrospective, single institutional cohort study. The primary outcome was death and reoperation. The secondary outcome was late clinical status, including exercise capacity. The peak oxygen uptake was measured by a ramp-like progressive exercise test on a treadmill. RESULTS: Nine patients underwent palliative surgery, which resulted in 2 deaths. Forty-eight patients went on to truncus arteriosus repair, including 17 neonates (35.4%). The median age and body weight at repair were 92.5 days (interquartile range, 10-272 days) and 3.85 kg (interquartile range, 2.9-6.5 kg), respectively. The survival rate at 30 years was 68.5%. Significant truncal valve regurgitation (P = .030) was a risk factor for survival. Survival rates were similar between in the early 25 and late 25 patients (P = .452). The freedom from death or reoperation rate at 15 years was 35.8%. Significant truncal valve regurgitation was a risk factor (P = .001). The mean follow-up period in hospital survivors was 15.4 ± 12 years (maximum, 43 years). The peak oxygen uptake, which was performed in 12 long-term survivors at a median duration from repair of 19.7 years (interquartile range, 16.8-30.9 years), was 70.2% of predicted normal (interquartile range, 64.5%-80.4%). CONCLUSIONS: Truncal valve regurgitation was a risk factor for both survival and reoperation, thus improvement of truncal valve surgery is essential for better life prognosis and quality of life. Slightly reduced exercise tolerance was common in long-term survivors. |
format | Online Article Text |
id | pubmed-10328806 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-103288062023-07-09 Death, reoperation, and late cardiopulmonary function after truncus repair Hoashi, Takaya Imai, Kenta Okuda, Naoki Komori, Motoki Ono, Yoshikazu Kurosaki, Kenichi Ichikawa, Hajime JTCVS Open Congenital: Truncus Arteriosus OBJECTIVE: To identify the late surgical outcomes of truncus arteriosus. METHODS: Fifty consecutive patients with truncus arteriosus who underwent surgery between 1978 and 2020 at our institute were enrolled in this retrospective, single institutional cohort study. The primary outcome was death and reoperation. The secondary outcome was late clinical status, including exercise capacity. The peak oxygen uptake was measured by a ramp-like progressive exercise test on a treadmill. RESULTS: Nine patients underwent palliative surgery, which resulted in 2 deaths. Forty-eight patients went on to truncus arteriosus repair, including 17 neonates (35.4%). The median age and body weight at repair were 92.5 days (interquartile range, 10-272 days) and 3.85 kg (interquartile range, 2.9-6.5 kg), respectively. The survival rate at 30 years was 68.5%. Significant truncal valve regurgitation (P = .030) was a risk factor for survival. Survival rates were similar between in the early 25 and late 25 patients (P = .452). The freedom from death or reoperation rate at 15 years was 35.8%. Significant truncal valve regurgitation was a risk factor (P = .001). The mean follow-up period in hospital survivors was 15.4 ± 12 years (maximum, 43 years). The peak oxygen uptake, which was performed in 12 long-term survivors at a median duration from repair of 19.7 years (interquartile range, 16.8-30.9 years), was 70.2% of predicted normal (interquartile range, 64.5%-80.4%). CONCLUSIONS: Truncal valve regurgitation was a risk factor for both survival and reoperation, thus improvement of truncal valve surgery is essential for better life prognosis and quality of life. Slightly reduced exercise tolerance was common in long-term survivors. Elsevier 2023-03-01 /pmc/articles/PMC10328806/ /pubmed/37425460 http://dx.doi.org/10.1016/j.xjon.2023.02.010 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Congenital: Truncus Arteriosus Hoashi, Takaya Imai, Kenta Okuda, Naoki Komori, Motoki Ono, Yoshikazu Kurosaki, Kenichi Ichikawa, Hajime Death, reoperation, and late cardiopulmonary function after truncus repair |
title | Death, reoperation, and late cardiopulmonary function after truncus repair |
title_full | Death, reoperation, and late cardiopulmonary function after truncus repair |
title_fullStr | Death, reoperation, and late cardiopulmonary function after truncus repair |
title_full_unstemmed | Death, reoperation, and late cardiopulmonary function after truncus repair |
title_short | Death, reoperation, and late cardiopulmonary function after truncus repair |
title_sort | death, reoperation, and late cardiopulmonary function after truncus repair |
topic | Congenital: Truncus Arteriosus |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10328806/ https://www.ncbi.nlm.nih.gov/pubmed/37425460 http://dx.doi.org/10.1016/j.xjon.2023.02.010 |
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