Kinome-wide CRISPR-Cas9 knockout screens revealed PLK1 as a therapeutic target for osteosarcoma

Osteosarcoma is the most common malignant bone tumor, tending to be aggressive and recurrent. The therapeutic development for treating osteosarcoma has been largely hampered by the lack of effective and specific targets. Using kinome-wide CRISPR-Cas9 knockout screens, we systematically revealed a co...

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Detalles Bibliográficos
Autores principales: Wang, Renxian, Wang, Dingding, Bai, Xueshan, Guo, Jianxun, Xia, Songxia, Cheng, Yuning, Gu, Yani, Wang, Qian, Nie, Jingjun, Chen, Dafu, Liu, Weifeng, Liang, Junbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10328921/
https://www.ncbi.nlm.nih.gov/pubmed/37419907
http://dx.doi.org/10.1038/s41420-023-01526-7

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