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Morphomigrational description as a new approach connecting cell's migration with its morphology

The examination of morphology and migration of cells plays substantial role in understanding the cellular behaviour, being described by plethora of quantitative parameters and models. These descriptions, however, treat cell migration and morphology as independent properties of temporal cell state, w...

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Autores principales: Kołodziej, Tomasz, Mielnicka, Aleksandra, Dziob, Daniel, Chojnacka, Anna Katarzyna, Rawski, Mateusz, Mazurkiewicz, Jan, Rajfur, Zenon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10328925/
https://www.ncbi.nlm.nih.gov/pubmed/37419901
http://dx.doi.org/10.1038/s41598-023-35827-9
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author Kołodziej, Tomasz
Mielnicka, Aleksandra
Dziob, Daniel
Chojnacka, Anna Katarzyna
Rawski, Mateusz
Mazurkiewicz, Jan
Rajfur, Zenon
author_facet Kołodziej, Tomasz
Mielnicka, Aleksandra
Dziob, Daniel
Chojnacka, Anna Katarzyna
Rawski, Mateusz
Mazurkiewicz, Jan
Rajfur, Zenon
author_sort Kołodziej, Tomasz
collection PubMed
description The examination of morphology and migration of cells plays substantial role in understanding the cellular behaviour, being described by plethora of quantitative parameters and models. These descriptions, however, treat cell migration and morphology as independent properties of temporal cell state, while not taking into account their strong interdependence in adherent cells. Here we present the new and simple mathematical parameter called signed morphomigrational angle (sMM angle) that links cell geometry with translocation of cell centroid, considering them as one morphomigrational behaviour. The sMM angle combined with pre-existing quantitative parameters enabled us to build a new tool called morphomigrational description, used to assign the numerical values to several cellular behaviours. Thus, the cellular activities that until now were characterized using verbal description or by complex mathematical models, are described here by a set of numbers. Our tool can be further used in automatic analysis of cell populations as well as in studies focused on cellular response to environmental directional signals.
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spelling pubmed-103289252023-07-09 Morphomigrational description as a new approach connecting cell's migration with its morphology Kołodziej, Tomasz Mielnicka, Aleksandra Dziob, Daniel Chojnacka, Anna Katarzyna Rawski, Mateusz Mazurkiewicz, Jan Rajfur, Zenon Sci Rep Article The examination of morphology and migration of cells plays substantial role in understanding the cellular behaviour, being described by plethora of quantitative parameters and models. These descriptions, however, treat cell migration and morphology as independent properties of temporal cell state, while not taking into account their strong interdependence in adherent cells. Here we present the new and simple mathematical parameter called signed morphomigrational angle (sMM angle) that links cell geometry with translocation of cell centroid, considering them as one morphomigrational behaviour. The sMM angle combined with pre-existing quantitative parameters enabled us to build a new tool called morphomigrational description, used to assign the numerical values to several cellular behaviours. Thus, the cellular activities that until now were characterized using verbal description or by complex mathematical models, are described here by a set of numbers. Our tool can be further used in automatic analysis of cell populations as well as in studies focused on cellular response to environmental directional signals. Nature Publishing Group UK 2023-07-07 /pmc/articles/PMC10328925/ /pubmed/37419901 http://dx.doi.org/10.1038/s41598-023-35827-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Kołodziej, Tomasz
Mielnicka, Aleksandra
Dziob, Daniel
Chojnacka, Anna Katarzyna
Rawski, Mateusz
Mazurkiewicz, Jan
Rajfur, Zenon
Morphomigrational description as a new approach connecting cell's migration with its morphology
title Morphomigrational description as a new approach connecting cell's migration with its morphology
title_full Morphomigrational description as a new approach connecting cell's migration with its morphology
title_fullStr Morphomigrational description as a new approach connecting cell's migration with its morphology
title_full_unstemmed Morphomigrational description as a new approach connecting cell's migration with its morphology
title_short Morphomigrational description as a new approach connecting cell's migration with its morphology
title_sort morphomigrational description as a new approach connecting cell's migration with its morphology
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10328925/
https://www.ncbi.nlm.nih.gov/pubmed/37419901
http://dx.doi.org/10.1038/s41598-023-35827-9
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