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Biomechanical analysis of novel leaflet geometries for bioprosthetic valves

OBJECTIVES: Although bioprosthetic valves have excellent hemodynamic properties and can eliminate the need for lifelong anticoagulation therapy, these devices are associated with high rates of reoperation and limited durability. Although there are many distinct bioprosthesis designs, all bioprosthet...

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Autores principales: Pandya, Pearly K., Park, Matthew H., Zhu, Yuanjia, Woo, Y. Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10328959/
https://www.ncbi.nlm.nih.gov/pubmed/37425479
http://dx.doi.org/10.1016/j.xjon.2023.04.007
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author Pandya, Pearly K.
Park, Matthew H.
Zhu, Yuanjia
Woo, Y. Joseph
author_facet Pandya, Pearly K.
Park, Matthew H.
Zhu, Yuanjia
Woo, Y. Joseph
author_sort Pandya, Pearly K.
collection PubMed
description OBJECTIVES: Although bioprosthetic valves have excellent hemodynamic properties and can eliminate the need for lifelong anticoagulation therapy, these devices are associated with high rates of reoperation and limited durability. Although there are many distinct bioprosthesis designs, all bioprosthetic valves have historically featured a trileaflet pattern. This in silico study examines the biomechanical effect of modulating the number of leaflets in a bioprosthetic valve. METHODS: Bioprosthetic valves with 2 to 6 leaflets were designed in Fusion 360 using quadratic spline geometry. Leaflets were modeled with standard mechanical parameters for fixed bovine pericardial tissue. A mesh of each design was structurally evaluated using finite element analysis software Abaqus CAE. Maximum von Mises stresses during valve closure were assessed for each leaflet geometry in both the aortic and mitral position. RESULTS: Computational analysis demonstrated that increasing the number of leaflets is associated with reduction in leaflet stresses. Compared with the standard trileaflet design, a quadrileaflet pattern reduces leaflet maximum von Mises stresses by 36% in the aortic position and 38% in the mitral position. Maximum stress was inversely proportional to the square of the leaflet quantity. Surface area increased linearly and central leakage increased quadratically with leaflet quantity. CONCLUSIONS: A quadrileaflet pattern was found to reduce leaflet stresses while limiting increases in central leakage and surface area. These findings suggest that modulating the number of leaflets can allow for optimization of the current bioprosthetic valve design, which may translate to more durable valve replacement bioprostheses.
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spelling pubmed-103289592023-07-09 Biomechanical analysis of novel leaflet geometries for bioprosthetic valves Pandya, Pearly K. Park, Matthew H. Zhu, Yuanjia Woo, Y. Joseph JTCVS Open Adult: Aortic Valve: Evolving Technology OBJECTIVES: Although bioprosthetic valves have excellent hemodynamic properties and can eliminate the need for lifelong anticoagulation therapy, these devices are associated with high rates of reoperation and limited durability. Although there are many distinct bioprosthesis designs, all bioprosthetic valves have historically featured a trileaflet pattern. This in silico study examines the biomechanical effect of modulating the number of leaflets in a bioprosthetic valve. METHODS: Bioprosthetic valves with 2 to 6 leaflets were designed in Fusion 360 using quadratic spline geometry. Leaflets were modeled with standard mechanical parameters for fixed bovine pericardial tissue. A mesh of each design was structurally evaluated using finite element analysis software Abaqus CAE. Maximum von Mises stresses during valve closure were assessed for each leaflet geometry in both the aortic and mitral position. RESULTS: Computational analysis demonstrated that increasing the number of leaflets is associated with reduction in leaflet stresses. Compared with the standard trileaflet design, a quadrileaflet pattern reduces leaflet maximum von Mises stresses by 36% in the aortic position and 38% in the mitral position. Maximum stress was inversely proportional to the square of the leaflet quantity. Surface area increased linearly and central leakage increased quadratically with leaflet quantity. CONCLUSIONS: A quadrileaflet pattern was found to reduce leaflet stresses while limiting increases in central leakage and surface area. These findings suggest that modulating the number of leaflets can allow for optimization of the current bioprosthetic valve design, which may translate to more durable valve replacement bioprostheses. Elsevier 2023-04-20 /pmc/articles/PMC10328959/ /pubmed/37425479 http://dx.doi.org/10.1016/j.xjon.2023.04.007 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Adult: Aortic Valve: Evolving Technology
Pandya, Pearly K.
Park, Matthew H.
Zhu, Yuanjia
Woo, Y. Joseph
Biomechanical analysis of novel leaflet geometries for bioprosthetic valves
title Biomechanical analysis of novel leaflet geometries for bioprosthetic valves
title_full Biomechanical analysis of novel leaflet geometries for bioprosthetic valves
title_fullStr Biomechanical analysis of novel leaflet geometries for bioprosthetic valves
title_full_unstemmed Biomechanical analysis of novel leaflet geometries for bioprosthetic valves
title_short Biomechanical analysis of novel leaflet geometries for bioprosthetic valves
title_sort biomechanical analysis of novel leaflet geometries for bioprosthetic valves
topic Adult: Aortic Valve: Evolving Technology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10328959/
https://www.ncbi.nlm.nih.gov/pubmed/37425479
http://dx.doi.org/10.1016/j.xjon.2023.04.007
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