Cargando…
A systematic review and meta-analysis of the prevalence of dyslipidaemia among adults in Malaysia
Dyslipidaemia is an established cardiovascular risk factor. This study aimed to determine the pooled prevalence of dyslipidaemia in Malaysian adults. A systematic review and meta-analysis of all cross-sectional, longitudinal observational studies which reported the prevalence of elevated total chole...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10328969/ https://www.ncbi.nlm.nih.gov/pubmed/37419924 http://dx.doi.org/10.1038/s41598-023-38275-7 |
_version_ | 1785069921645887488 |
---|---|
author | Mohamed-Yassin, Mohamed-Syarif Rosman, Norhidayah Kamaruddin, Khairatul Nainey Miptah, Hayatul Najaa Baharudin, Noorhida Ramli, Anis Safura Abdul-Razak, Suraya Lai, Nai Ming |
author_facet | Mohamed-Yassin, Mohamed-Syarif Rosman, Norhidayah Kamaruddin, Khairatul Nainey Miptah, Hayatul Najaa Baharudin, Noorhida Ramli, Anis Safura Abdul-Razak, Suraya Lai, Nai Ming |
author_sort | Mohamed-Yassin, Mohamed-Syarif |
collection | PubMed |
description | Dyslipidaemia is an established cardiovascular risk factor. This study aimed to determine the pooled prevalence of dyslipidaemia in Malaysian adults. A systematic review and meta-analysis of all cross-sectional, longitudinal observational studies which reported the prevalence of elevated total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), triglycerides (TG), and reduced high-density lipoprotein cholesterol (HDL-c) in adults 18 years old and older, was conducted. A comprehensive search of PubMed and Cochrane Central Register of Controlled Trials (which included Medline, EMBASE and major trial registers) from inception to October 18, 2022, was performed. Risk-of-bias was evaluated using the Johanna-Briggs Institute Prevalence Critical Appraisal Tool, while certainty of evidence was assessed using an adapted version of the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) framework. Random-effects meta-analyses were performed using MetaXL. This report follows the PRISMA reporting guidelines. The protocol was registered with PROSPERO (CRD42020200281). 26 556 studies were retrieved and 7 941 were shortlisted initially. From this, 70 Malaysian studies plus two studies from citation searching were shortlisted; 46 were excluded, and 26 were included in the review (n = 50 001). The pooled prevalence of elevated TC (≥ 5.2 mmol/L), elevated LDL-c (≥ 2.6 mmol/L), elevated TG (≥ 1.7 mmol/L), and low HDL-c (< 1.0 mmol/L in men and < 1.3 mmol/L in women) were 53% (95% CI 39–67%, I(2) = 100%), 73% (95% CI 50–92%, I(2) = 100%), 36% (95% CI 32–40%, I(2) = 96%), and 40% (95% CI 25–55%, I(2) = 99%), respectively. This review found that the prevalence of all dyslipidaemia subtypes is high in Malaysian adults. Ongoing efforts to reduce cardiovascular diseases in Malaysia should integrate effective detection and treatment of dyslipidaemia. |
format | Online Article Text |
id | pubmed-10328969 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-103289692023-07-09 A systematic review and meta-analysis of the prevalence of dyslipidaemia among adults in Malaysia Mohamed-Yassin, Mohamed-Syarif Rosman, Norhidayah Kamaruddin, Khairatul Nainey Miptah, Hayatul Najaa Baharudin, Noorhida Ramli, Anis Safura Abdul-Razak, Suraya Lai, Nai Ming Sci Rep Article Dyslipidaemia is an established cardiovascular risk factor. This study aimed to determine the pooled prevalence of dyslipidaemia in Malaysian adults. A systematic review and meta-analysis of all cross-sectional, longitudinal observational studies which reported the prevalence of elevated total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), triglycerides (TG), and reduced high-density lipoprotein cholesterol (HDL-c) in adults 18 years old and older, was conducted. A comprehensive search of PubMed and Cochrane Central Register of Controlled Trials (which included Medline, EMBASE and major trial registers) from inception to October 18, 2022, was performed. Risk-of-bias was evaluated using the Johanna-Briggs Institute Prevalence Critical Appraisal Tool, while certainty of evidence was assessed using an adapted version of the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) framework. Random-effects meta-analyses were performed using MetaXL. This report follows the PRISMA reporting guidelines. The protocol was registered with PROSPERO (CRD42020200281). 26 556 studies were retrieved and 7 941 were shortlisted initially. From this, 70 Malaysian studies plus two studies from citation searching were shortlisted; 46 were excluded, and 26 were included in the review (n = 50 001). The pooled prevalence of elevated TC (≥ 5.2 mmol/L), elevated LDL-c (≥ 2.6 mmol/L), elevated TG (≥ 1.7 mmol/L), and low HDL-c (< 1.0 mmol/L in men and < 1.3 mmol/L in women) were 53% (95% CI 39–67%, I(2) = 100%), 73% (95% CI 50–92%, I(2) = 100%), 36% (95% CI 32–40%, I(2) = 96%), and 40% (95% CI 25–55%, I(2) = 99%), respectively. This review found that the prevalence of all dyslipidaemia subtypes is high in Malaysian adults. Ongoing efforts to reduce cardiovascular diseases in Malaysia should integrate effective detection and treatment of dyslipidaemia. Nature Publishing Group UK 2023-07-07 /pmc/articles/PMC10328969/ /pubmed/37419924 http://dx.doi.org/10.1038/s41598-023-38275-7 Text en © The Author(s) 2023, corrected publication 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Mohamed-Yassin, Mohamed-Syarif Rosman, Norhidayah Kamaruddin, Khairatul Nainey Miptah, Hayatul Najaa Baharudin, Noorhida Ramli, Anis Safura Abdul-Razak, Suraya Lai, Nai Ming A systematic review and meta-analysis of the prevalence of dyslipidaemia among adults in Malaysia |
title | A systematic review and meta-analysis of the prevalence of dyslipidaemia among adults in Malaysia |
title_full | A systematic review and meta-analysis of the prevalence of dyslipidaemia among adults in Malaysia |
title_fullStr | A systematic review and meta-analysis of the prevalence of dyslipidaemia among adults in Malaysia |
title_full_unstemmed | A systematic review and meta-analysis of the prevalence of dyslipidaemia among adults in Malaysia |
title_short | A systematic review and meta-analysis of the prevalence of dyslipidaemia among adults in Malaysia |
title_sort | systematic review and meta-analysis of the prevalence of dyslipidaemia among adults in malaysia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10328969/ https://www.ncbi.nlm.nih.gov/pubmed/37419924 http://dx.doi.org/10.1038/s41598-023-38275-7 |
work_keys_str_mv | AT mohamedyassinmohamedsyarif asystematicreviewandmetaanalysisoftheprevalenceofdyslipidaemiaamongadultsinmalaysia AT rosmannorhidayah asystematicreviewandmetaanalysisoftheprevalenceofdyslipidaemiaamongadultsinmalaysia AT kamaruddinkhairatulnainey asystematicreviewandmetaanalysisoftheprevalenceofdyslipidaemiaamongadultsinmalaysia AT miptahhayatulnajaa asystematicreviewandmetaanalysisoftheprevalenceofdyslipidaemiaamongadultsinmalaysia AT baharudinnoorhida asystematicreviewandmetaanalysisoftheprevalenceofdyslipidaemiaamongadultsinmalaysia AT ramlianissafura asystematicreviewandmetaanalysisoftheprevalenceofdyslipidaemiaamongadultsinmalaysia AT abdulrazaksuraya asystematicreviewandmetaanalysisoftheprevalenceofdyslipidaemiaamongadultsinmalaysia AT lainaiming asystematicreviewandmetaanalysisoftheprevalenceofdyslipidaemiaamongadultsinmalaysia AT asystematicreviewandmetaanalysisoftheprevalenceofdyslipidaemiaamongadultsinmalaysia AT mohamedyassinmohamedsyarif systematicreviewandmetaanalysisoftheprevalenceofdyslipidaemiaamongadultsinmalaysia AT rosmannorhidayah systematicreviewandmetaanalysisoftheprevalenceofdyslipidaemiaamongadultsinmalaysia AT kamaruddinkhairatulnainey systematicreviewandmetaanalysisoftheprevalenceofdyslipidaemiaamongadultsinmalaysia AT miptahhayatulnajaa systematicreviewandmetaanalysisoftheprevalenceofdyslipidaemiaamongadultsinmalaysia AT baharudinnoorhida systematicreviewandmetaanalysisoftheprevalenceofdyslipidaemiaamongadultsinmalaysia AT ramlianissafura systematicreviewandmetaanalysisoftheprevalenceofdyslipidaemiaamongadultsinmalaysia AT abdulrazaksuraya systematicreviewandmetaanalysisoftheprevalenceofdyslipidaemiaamongadultsinmalaysia AT lainaiming systematicreviewandmetaanalysisoftheprevalenceofdyslipidaemiaamongadultsinmalaysia AT systematicreviewandmetaanalysisoftheprevalenceofdyslipidaemiaamongadultsinmalaysia |