Amino acid homeostasis is a target of metformin therapy

OBJECTIVE: Unexplained changes in regulation of branched chain amino acids (BCAA) during diabetes therapy with metformin have been known for years. Here we have investigated mechanisms underlying this effect. METHODS: We used cellular approaches, including single gene/protein measurements, as well a...

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Detalles Bibliográficos
Autores principales: Forteath, Calum, Mordi, Ify, Nisr, Raid, Gutierrez-Lara, Erika J., Alqurashi, Noor, Phair, Iain R., Cameron, Amy R., Beall, Craig, Bahr, Ibrahim, Mohan, Mohapradeep, Wong, Aaron K.F., Dihoum, Adel, Mohammad, Anwar, Palmer, Colin N.A., Lamont, Douglas, Sakamoto, Kei, Viollet, Benoit, Foretz, Marc, Lang, Chim C., Rena, Graham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10328998/
https://www.ncbi.nlm.nih.gov/pubmed/37302544
http://dx.doi.org/10.1016/j.molmet.2023.101750

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