Endothelial cell CD36 regulates membrane ceramide formation, exosome fatty acid transfer and circulating fatty acid levels

Endothelial cell (EC) CD36 controls tissue fatty acid (FA) uptake. Here we examine how ECs transfer FAs. FA interaction with apical membrane CD36 induces Src phosphorylation of caveolin-1 tyrosine-14 (Cav-1Y14) and ceramide generation in caveolae. Ensuing fission of caveolae yields vesicles containi...

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Detalles Bibliográficos
Autores principales: Peche, V. S., Pietka, T. A., Jacome-Sosa, M., Samovski, D., Palacios, H., Chatterjee-Basu, G., Dudley, A. C., Beatty, W., Meyer, G. A., Goldberg, I. J., Abumrad, N. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10329018/
https://www.ncbi.nlm.nih.gov/pubmed/37419919
http://dx.doi.org/10.1038/s41467-023-39752-3

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