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Genome-wide CRISPR-Cas9 screen analyzed by SLIDER identifies network of repressor complexes that regulate TRIM24

TRIM24 is an oncogenic chromatin reader that is frequently overexpressed in human tumors and associated with poor prognosis. However, TRIM24 is rarely mutated, duplicated, or rearranged in cancer. This raises questions about how TRIM24 is regulated and what changes in its regulation are responsible...

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Detalles Bibliográficos
Autores principales:	Patel, Lalit R., Stratton, Sabrina A., McLaughlin, Megan, Krause, Patrick, Allton, Kendra, Rivas, Andrés López, Barbosa, Daniela, Hart, Traver, Barton, Michelle C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10329041/ https://www.ncbi.nlm.nih.gov/pubmed/37426340 http://dx.doi.org/10.1016/j.isci.2023.107126

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