Calcium dysregulation combined with mitochondrial failure and electrophysiological maturity converge in Parkinson’s iPSC-dopamine neurons

Parkinson’s disease (PD) is characterized by a progressive deterioration of motor and cognitive functions. Although death of dopamine neurons is the hallmark pathology of PD, this is a late-stage disease process preceded by neuronal dysfunction. Here we describe early physiological perturbations in...

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Detalles Bibliográficos
Autores principales: Beccano-Kelly, Dayne A., Cherubini, Marta, Mousba, Yassine, Cramb, Kaitlyn M.L., Giussani, Stefania, Caiazza, Maria Claudia, Rai, Pavandeep, Vingill, Siv, Bengoa-Vergniory, Nora, Ng, Bryan, Corda, Gabriele, Banerjee, Abhirup, Vowles, Jane, Cowley, Sally, Wade-Martins, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10329047/
https://www.ncbi.nlm.nih.gov/pubmed/37426342
http://dx.doi.org/10.1016/j.isci.2023.107044

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