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Pulmonary thromboembolism and obesity in forensic pathologic case work
328 autopsy cases of fatal pulmonary thromboembolism (PE) were compared to 984 age- and sex-matched controls to evaluate the association between obesity and PE in a forensic context. Both PE and control cases had a mean age of 67,8 years (male 62,9 years, females 71,7 years). The percentage of morbi...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer US
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10329082/ https://www.ncbi.nlm.nih.gov/pubmed/36943647 http://dx.doi.org/10.1007/s12024-023-00602-9 |
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author | Klintschar, Michael Wöllner, Kirsten Hagemeier, Lars Engelmann, Theresa A. Mahlmann, Jan Lunow, Alessia Wolff-Maras, Roman |
author_facet | Klintschar, Michael Wöllner, Kirsten Hagemeier, Lars Engelmann, Theresa A. Mahlmann, Jan Lunow, Alessia Wolff-Maras, Roman |
author_sort | Klintschar, Michael |
collection | PubMed |
description | 328 autopsy cases of fatal pulmonary thromboembolism (PE) were compared to 984 age- and sex-matched controls to evaluate the association between obesity and PE in a forensic context. Both PE and control cases had a mean age of 67,8 years (male 62,9 years, females 71,7 years). The percentage of morbidly obese persons with a body mass index (BMI) of above 40 or abdominal subcutaneous adipose tissue of above 4 cm was higher in the PE group (8,39% vs. 4,67% and 29.45% vs. 23.40%, respectively). On the other side, that of very slim persons (BMI below 18.5 or adipose tissue below 3 cm) was significantly smaller (4,27% vs. 7,52% and 47.55% vs. 56,60%). We thus found a strong association between being overweight and death from PE, while slim persons seem to be at an advantage. As the group of underweight persons includes those suffering from chronic diseases with reduced mobility or hypercoagulability (e.g. tumor kachexia or sarkopenia due to immobilisation), this finding is to some extent unexpected. |
format | Online Article Text |
id | pubmed-10329082 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-103290822023-07-09 Pulmonary thromboembolism and obesity in forensic pathologic case work Klintschar, Michael Wöllner, Kirsten Hagemeier, Lars Engelmann, Theresa A. Mahlmann, Jan Lunow, Alessia Wolff-Maras, Roman Forensic Sci Med Pathol Original Article 328 autopsy cases of fatal pulmonary thromboembolism (PE) were compared to 984 age- and sex-matched controls to evaluate the association between obesity and PE in a forensic context. Both PE and control cases had a mean age of 67,8 years (male 62,9 years, females 71,7 years). The percentage of morbidly obese persons with a body mass index (BMI) of above 40 or abdominal subcutaneous adipose tissue of above 4 cm was higher in the PE group (8,39% vs. 4,67% and 29.45% vs. 23.40%, respectively). On the other side, that of very slim persons (BMI below 18.5 or adipose tissue below 3 cm) was significantly smaller (4,27% vs. 7,52% and 47.55% vs. 56,60%). We thus found a strong association between being overweight and death from PE, while slim persons seem to be at an advantage. As the group of underweight persons includes those suffering from chronic diseases with reduced mobility or hypercoagulability (e.g. tumor kachexia or sarkopenia due to immobilisation), this finding is to some extent unexpected. Springer US 2023-03-21 2023 /pmc/articles/PMC10329082/ /pubmed/36943647 http://dx.doi.org/10.1007/s12024-023-00602-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Klintschar, Michael Wöllner, Kirsten Hagemeier, Lars Engelmann, Theresa A. Mahlmann, Jan Lunow, Alessia Wolff-Maras, Roman Pulmonary thromboembolism and obesity in forensic pathologic case work |
title | Pulmonary thromboembolism and obesity in forensic pathologic case work |
title_full | Pulmonary thromboembolism and obesity in forensic pathologic case work |
title_fullStr | Pulmonary thromboembolism and obesity in forensic pathologic case work |
title_full_unstemmed | Pulmonary thromboembolism and obesity in forensic pathologic case work |
title_short | Pulmonary thromboembolism and obesity in forensic pathologic case work |
title_sort | pulmonary thromboembolism and obesity in forensic pathologic case work |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10329082/ https://www.ncbi.nlm.nih.gov/pubmed/36943647 http://dx.doi.org/10.1007/s12024-023-00602-9 |
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