CAFs targeted ultrasound-responsive nanodroplets loaded V9302 and GLULsiRNA to inhibit melanoma growth via glutamine metabolic reprogramming and tumor microenvironment remodeling

Despite rapid advances in metabolic therapies over the past decade, their efficacy in melanoma has been modest, largely due to the interaction between cancer-associated fibroblasts (CAFs) and cancer cells to promote cancer growth. Altering the tumor microenvironment (TME) is challenging and elusive....

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Detalles Bibliográficos
Autores principales: Ai, Chen, Sun, Xiao, Xiao, Shan, Guo, Lu, Shang, Mengmeng, Shi, Dandan, Meng, Dong, Zhao, Yading, Wang, Xiaoxuan, Li, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10329298/
https://www.ncbi.nlm.nih.gov/pubmed/37420266
http://dx.doi.org/10.1186/s12951-023-01979-z

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