Cargando…

Cellular hierarchy framework based on single-cell/multi-patient sample sequencing reveals metabolic biomarker PYGL as a therapeutic target for HNSCC

BACKGROUND: A growing body of research has revealed the connection of metabolism reprogramming and tumor progression, yet how metabolism reprogramming affects inter-patient heterogeneity and prognosis in head and neck squamous cell carcinoma (HNSCC) still requires further explorations. METHODS: A ce...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guan, Jiezhong, Xu, Xi, Qiu, Guo, He, Chong, Lu, Xiaoyue, Wang, Kang, Liu, Xinyu, Li, Yuanyuan, Ling, Zihang, Tang, Xuan, Liang, Yujie, Tao, Xiaoan, Cheng, Bin, Yang, Bo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10329320/ https://www.ncbi.nlm.nih.gov/pubmed/37420300 http://dx.doi.org/10.1186/s13046-023-02734-w

Ejemplares similares

High PYGL Expression Predicts Poor Prognosis in Human Gliomas
por: Zhao, Chang-yi, et al.
Publicado: (2021)

PYGL-mediated glucose metabolism reprogramming promotes EMT phenotype and metastasis of pancreatic cancer
por: Ji, Qian, et al.
Publicado: (2023)

Novel PYGL mutations in Chinese children leading to glycogen storage disease type VI: two case reports
por: Luo, Xiaomei, et al.
Publicado: (2020)

Hepatic glycogenolysis is determined by maternal high-calorie diet via methylation of Pygl and it is modified by oteocalcin administration in mice
por: Kawakubo-Yasukochi, Tomoyo, et al.
Publicado: (2021)

Glycogen storage disease type VI with a novel PYGL mutation: Two case reports and literature review
por: Zhan, Qian, et al.
Publicado: (2021)

miR-155-5p regulates hypoxia-induced pulmonary artery smooth muscle cell function by targeting PYGL
por: Wang, Guowen, et al.
Publicado: (2022)

Hierarchy in Metal–Organic Frameworks
por: Feng, Liang, et al.
Publicado: (2020)

Long noncoding RNA KCNMB2-AS1 promotes the development of esophageal cancer by modulating the miR-3194-3p/PYGL axis
por: Xu, Jiwen, et al.
Publicado: (2021)

NTF2 Upregulation in HNSCC: a Predictive Marker and Potential Therapeutic Target Associated With Immune Infiltration
por: Xuan, Guangxu, et al.
Publicado: (2022)

The mammary cellular hierarchy and breast cancer
por: Oakes, Samantha R., et al.
Publicado: (2014)

PD-L2 based immune signature confers poor prognosis in HNSCC
por: Qiao, Yu, et al.
Publicado: (2021)

EHF is a novel regulator of cellular redox metabolism and predicts patient prognosis in HNSCC
por: Oyelakin, Akinsola, et al.
Publicado: (2022)

Incidence and survival of HNSCC patients living with HIV compared with HIV-negative HNSCC patients
por: Haase, Katharina, et al.
Publicado: (2021)

Representing Route Familiarity Using the Abstraction Hierarchy Framework
por: Payyanadan, Rashmi P., et al.
Publicado: (2021)

Quercetin suppresses cellular migration and invasion in human head and neck squamous cell carcinoma (HNSCC)
por: Chan, Chien-Yi, et al.
Publicado: (2016)

A single-cell survey of cellular hierarchy in acute myeloid leukemia
por: Wu, Junqing, et al.
Publicado: (2020)

CD73 is associated with poor prognosis in HNSCC
por: Ren, Zhen-Hu, et al.
Publicado: (2016)

Extracting a Cellular Hierarchy from High-dimensional Cytometry Data with SPADE
por: Qiu, Peng, et al.
Publicado: (2011)

Hierarchy of cellular decisions in collective behavior: Implications for wound healing
por: Wickert, Lisa E., et al.
Publicado: (2016)

A hierarchy of gauge hierarchies
por: Ellis, Jonathan Richard, et al.
Publicado: (1979)

lncRNA in HNSCC: challenges and potential
por: Guglas, Kacper, et al.
Publicado: (2017)

HNSCC: Tumour Antigens and Their Targeting by Immunotherapy
por: von Witzleben, Adrian, et al.
Publicado: (2020)

NF-Y Subunits Overexpression in HNSCC
por: Bezzecchi, Eugenia, et al.
Publicado: (2021)

The Impact of YRNAs on HNSCC and HPV Infection
por: Guglas, Kacper, et al.
Publicado: (2023)

Targeting methyltransferase PRMT5 retards the carcinogenesis and metastasis of HNSCC via epigenetically inhibiting Twist1 transcription
por: Fan, Zhaona, et al.
Publicado: (2020)

Analysis of myosin genes in HNSCC and identify MYL1 as a specific poor prognostic biomarker, promotes tumor metastasis and correlates with tumor immune infiltration in HNSCC
por: Li, Ce, et al.
Publicado: (2023)

Inhibitory Effect of 1,8-Cineol on β-Catenin Regulation, WNT11 Expression, and Cellular Progression in HNSCC
por: Roettger, Anna, et al.
Publicado: (2017)

Generating New FANCA-Deficient HNSCC Cell Lines by Genomic Editing Recapitulates the Cellular Phenotypes of Fanconi Anemia
por: Errazquin, Ricardo, et al.
Publicado: (2021)

Defining the cellular lineage hierarchy in the inter-follicular epidermis of adult skin
por: Sada, Aiko, et al.
Publicado: (2016)

Quantitative single-cell proteomics as a tool to characterize cellular hierarchies
por: Schoof, Erwin M., et al.
Publicado: (2021)

Impact and Relevance of the Unfolded Protein Response in HNSCC
por: Pluquet, Olivier, et al.
Publicado: (2019)

Analyzing expression and phosphorylation of the EGF receptor in HNSCC
por: Kriegs, Malte, et al.
Publicado: (2019)

Review of biomarkers for response to immunotherapy in HNSCC microenvironment
por: Chen, Shaoshi, et al.
Publicado: (2023)

ANO1 amplification and expression in HNSCC with a high propensity for future distant metastasis and its functions in HNSCC cell lines
por: Ayoub, C, et al.
Publicado: (2010)

A meta-validated immune infiltration-related gene model predicts prognosis and immunotherapy sensitivity in HNSCC
por: Ding, Yinghe, et al.
Publicado: (2023)

Asymmetric sampling in human auditory cortex reveals spectral processing hierarchy
por: Giroud, Jérémy, et al.
Publicado: (2020)

Cellular-Level Versus Receptor-Level Response Threshold Hierarchies in T-Cell Activation
por: van den Berg, Hugo A., et al.
Publicado: (2013)

Mapping Informative Clusters in a Hierarchial Framework of fMRI Multivariate Analysis
por: Xu, Rui, et al.
Publicado: (2010)

Graph hierarchy: a novel framework to analyse hierarchical structures in complex networks
por: Moutsinas, Giannis, et al.
Publicado: (2021)

Identification of a novel necroptosis-associated miRNA signature for predicting the prognosis in head and neck squamous cell carcinoma
por: Guan, Jiezhong, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_llusleru4dr7uv53uvplkhk5rp