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Targeting macrophagic PIM-1 alleviates osteoarthritis by inhibiting NLRP3 inflammasome activation via suppressing mitochondrial ROS/Cl(−) efflux signaling pathway

BACKGROUND: Osteoarthritis (OA), in which macrophage-driven synovitis is considered closely related to cartilage destruction and could occur at any stage, is an inflammatory arthritis. However, there are no effective targets to cure the progression of OA. The NOD-, LRR-,and pyrin domain-containing p...

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Detalles Bibliográficos
Autores principales:	Zhang, Zhen, Xie, Shujun, Qian, Jin, Gao, Fengqiang, Jin, Wenjian, Wang, Lingqiao, Yan, Lili, Chen, Hao, Yao, Wangxiang, Li, Maoqiang, Wang, Xuepeng, Zhu, Liulong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10329339/ https://www.ncbi.nlm.nih.gov/pubmed/37422640 http://dx.doi.org/10.1186/s12967-023-04313-1

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