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A Metastatic Invasive Mole in a Perimenopausal Woman: A Rare Case

Gestational trophoblastic neoplasia (GTN) represents a heterogeneous group of pregnancy-related tumors that usually develop from the malignant transformation of trophoblastic tissue after molar evacuation. The first presentation as an invasive mole is particularly rare. GTN is considered the most cu...

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Autores principales: Tomé, Ana I, Palma, Rita, Antunes, Sofia Carralas, Tavares, Madalena A, Pereira, Elisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10329411/
https://www.ncbi.nlm.nih.gov/pubmed/37425576
http://dx.doi.org/10.7759/cureus.40121
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author Tomé, Ana I
Palma, Rita
Antunes, Sofia Carralas
Tavares, Madalena A
Pereira, Elisa
author_facet Tomé, Ana I
Palma, Rita
Antunes, Sofia Carralas
Tavares, Madalena A
Pereira, Elisa
author_sort Tomé, Ana I
collection PubMed
description Gestational trophoblastic neoplasia (GTN) represents a heterogeneous group of pregnancy-related tumors that usually develop from the malignant transformation of trophoblastic tissue after molar evacuation. The first presentation as an invasive mole is particularly rare. GTN is considered the most curable gynecological malignancy as most cases are treated successfully with chemotherapy agents. Although extremes of reproductive age are an established risk factor for complete moles, GTN is extremely rare in perimenopausal women. GTN should be considered in the differential diagnosis of patients with abnormal uterine bleeding. Delays in the diagnosis and treatment can worsen the prognosis of patients with GTN. Here, we describe the case of a 54-year-old woman who presented to the emergency department with abdominal pain and heavy vaginal bleeding. She reported pregnancy-related symptoms that had developed over two months but was apprehensive to search for medical care. The final diagnosis was an invasive mole that had a catastrophic clinical course. Arterial embolization should be considered in patients with uncontrollable vaginal bleeding and hemodynamic instability.
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spelling pubmed-103294112023-07-09 A Metastatic Invasive Mole in a Perimenopausal Woman: A Rare Case Tomé, Ana I Palma, Rita Antunes, Sofia Carralas Tavares, Madalena A Pereira, Elisa Cureus Obstetrics/Gynecology Gestational trophoblastic neoplasia (GTN) represents a heterogeneous group of pregnancy-related tumors that usually develop from the malignant transformation of trophoblastic tissue after molar evacuation. The first presentation as an invasive mole is particularly rare. GTN is considered the most curable gynecological malignancy as most cases are treated successfully with chemotherapy agents. Although extremes of reproductive age are an established risk factor for complete moles, GTN is extremely rare in perimenopausal women. GTN should be considered in the differential diagnosis of patients with abnormal uterine bleeding. Delays in the diagnosis and treatment can worsen the prognosis of patients with GTN. Here, we describe the case of a 54-year-old woman who presented to the emergency department with abdominal pain and heavy vaginal bleeding. She reported pregnancy-related symptoms that had developed over two months but was apprehensive to search for medical care. The final diagnosis was an invasive mole that had a catastrophic clinical course. Arterial embolization should be considered in patients with uncontrollable vaginal bleeding and hemodynamic instability. Cureus 2023-06-08 /pmc/articles/PMC10329411/ /pubmed/37425576 http://dx.doi.org/10.7759/cureus.40121 Text en Copyright © 2023, Tomé et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Obstetrics/Gynecology
Tomé, Ana I
Palma, Rita
Antunes, Sofia Carralas
Tavares, Madalena A
Pereira, Elisa
A Metastatic Invasive Mole in a Perimenopausal Woman: A Rare Case
title A Metastatic Invasive Mole in a Perimenopausal Woman: A Rare Case
title_full A Metastatic Invasive Mole in a Perimenopausal Woman: A Rare Case
title_fullStr A Metastatic Invasive Mole in a Perimenopausal Woman: A Rare Case
title_full_unstemmed A Metastatic Invasive Mole in a Perimenopausal Woman: A Rare Case
title_short A Metastatic Invasive Mole in a Perimenopausal Woman: A Rare Case
title_sort metastatic invasive mole in a perimenopausal woman: a rare case
topic Obstetrics/Gynecology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10329411/
https://www.ncbi.nlm.nih.gov/pubmed/37425576
http://dx.doi.org/10.7759/cureus.40121
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