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Association of Chronic Periodontitis with Helicobacter pylori Infection in Stomach or Mouth: A Systematic Review and Meta-Analysis

Helicobacter pylori ( H. pylori ) infection and periodontitis are both inflammatory conditions associated with systemic diseases. Researchers have attempted to investigate the correlation between them. This systematic review and meta-analyses were conducted to investigate the association of H. pylor...

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Autores principales: Tsimpiris, Athanasios, Tsolianos, Ioannis, Grigoriadis, Andreas, Moschos, Ioannis, Goulis, Dimitrios G., Kouklakis, Georgios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Medical and Scientific Publishers Pvt. Ltd. 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10329527/
https://www.ncbi.nlm.nih.gov/pubmed/36400109
http://dx.doi.org/10.1055/s-0042-1756690
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author Tsimpiris, Athanasios
Tsolianos, Ioannis
Grigoriadis, Andreas
Moschos, Ioannis
Goulis, Dimitrios G.
Kouklakis, Georgios
author_facet Tsimpiris, Athanasios
Tsolianos, Ioannis
Grigoriadis, Andreas
Moschos, Ioannis
Goulis, Dimitrios G.
Kouklakis, Georgios
author_sort Tsimpiris, Athanasios
collection PubMed
description Helicobacter pylori ( H. pylori ) infection and periodontitis are both inflammatory conditions associated with systemic diseases. Researchers have attempted to investigate the correlation between them. This systematic review and meta-analyses were conducted to investigate the association of H. pylori infection in the stomach and/or in subgingival plaque and gingival crevicular fluid with chronic periodontitis. The protocol was created according to the Preferred Reporting Items for Systematic review and Meta-Analysis Protocols (PRISMA-P) statement. The study was designed according to the Cochrane criteria. A comprehensive literature search was performed in MEDLINE, Scopus, and CENTRAL, combined with hand-searching and assessment of gray literature. The meta-analysis of the included studies was made by the Review Manager (RevMan) 5.4 software. The effect measure of the outcome was odds ratios with 95% confidence intervals. Heterogeneity was assessed by chi-square and I (2) . Four observational studies involving 818 subjects were included in this meta-analysis. The odds of oral H. pylori presence were higher in patients with chronic periodontitis, compared to healthy controls, with an odds ratio of 1.87 (95% confidence interval 0.85–4.10; p = 0.12). The odds of the presence of H. pylori in the stomach also were higher in patients with chronic periodontitis, with an odds ratio of 1.80 (95% confidence interval 0.82–3.95; p  = 0.15). There is no evidence for an association between chronic periodontitis and the prevalence of H. pylori , detected either in subgingival plaque and gingival crevicular fluid or in the stomach.
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spelling pubmed-103295272023-07-09 Association of Chronic Periodontitis with Helicobacter pylori Infection in Stomach or Mouth: A Systematic Review and Meta-Analysis Tsimpiris, Athanasios Tsolianos, Ioannis Grigoriadis, Andreas Moschos, Ioannis Goulis, Dimitrios G. Kouklakis, Georgios Eur J Dent Helicobacter pylori ( H. pylori ) infection and periodontitis are both inflammatory conditions associated with systemic diseases. Researchers have attempted to investigate the correlation between them. This systematic review and meta-analyses were conducted to investigate the association of H. pylori infection in the stomach and/or in subgingival plaque and gingival crevicular fluid with chronic periodontitis. The protocol was created according to the Preferred Reporting Items for Systematic review and Meta-Analysis Protocols (PRISMA-P) statement. The study was designed according to the Cochrane criteria. A comprehensive literature search was performed in MEDLINE, Scopus, and CENTRAL, combined with hand-searching and assessment of gray literature. The meta-analysis of the included studies was made by the Review Manager (RevMan) 5.4 software. The effect measure of the outcome was odds ratios with 95% confidence intervals. Heterogeneity was assessed by chi-square and I (2) . Four observational studies involving 818 subjects were included in this meta-analysis. The odds of oral H. pylori presence were higher in patients with chronic periodontitis, compared to healthy controls, with an odds ratio of 1.87 (95% confidence interval 0.85–4.10; p = 0.12). The odds of the presence of H. pylori in the stomach also were higher in patients with chronic periodontitis, with an odds ratio of 1.80 (95% confidence interval 0.82–3.95; p  = 0.15). There is no evidence for an association between chronic periodontitis and the prevalence of H. pylori , detected either in subgingival plaque and gingival crevicular fluid or in the stomach. Thieme Medical and Scientific Publishers Pvt. Ltd. 2022-11-18 /pmc/articles/PMC10329527/ /pubmed/36400109 http://dx.doi.org/10.1055/s-0042-1756690 Text en The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. ( https://creativecommons.org/licenses/by/4.0/ ) https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Tsimpiris, Athanasios
Tsolianos, Ioannis
Grigoriadis, Andreas
Moschos, Ioannis
Goulis, Dimitrios G.
Kouklakis, Georgios
Association of Chronic Periodontitis with Helicobacter pylori Infection in Stomach or Mouth: A Systematic Review and Meta-Analysis
title Association of Chronic Periodontitis with Helicobacter pylori Infection in Stomach or Mouth: A Systematic Review and Meta-Analysis
title_full Association of Chronic Periodontitis with Helicobacter pylori Infection in Stomach or Mouth: A Systematic Review and Meta-Analysis
title_fullStr Association of Chronic Periodontitis with Helicobacter pylori Infection in Stomach or Mouth: A Systematic Review and Meta-Analysis
title_full_unstemmed Association of Chronic Periodontitis with Helicobacter pylori Infection in Stomach or Mouth: A Systematic Review and Meta-Analysis
title_short Association of Chronic Periodontitis with Helicobacter pylori Infection in Stomach or Mouth: A Systematic Review and Meta-Analysis
title_sort association of chronic periodontitis with helicobacter pylori infection in stomach or mouth: a systematic review and meta-analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10329527/
https://www.ncbi.nlm.nih.gov/pubmed/36400109
http://dx.doi.org/10.1055/s-0042-1756690
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