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The effect of hematopoietic stem cell transplantation on patient-reported subjective oral dryness: a systematic review focusing on prevalence, severity and distress
OBJECTIVE: The aim of the present systematic review is to assess the prevalence and severity of and distress caused by xerostomia over time in adult hematopoietic stem cell transplantation (HSCT) recipients. METHODS: PubMed, Embase, and the Cochrane Library were searched for papers published between...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10329604/ https://www.ncbi.nlm.nih.gov/pubmed/37421511 http://dx.doi.org/10.1007/s00520-023-07921-1 |
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author | Bulthuis, Marjolein S. van Gennip, Lucky L. A. Bronkhorst, Ewald M. Blijlevens, Nicole M. A. Huysmans, Marie-Charlotte D. N. J. M. van Leeuwen, Stephanie J. M. Thomas, Renske Z. |
author_facet | Bulthuis, Marjolein S. van Gennip, Lucky L. A. Bronkhorst, Ewald M. Blijlevens, Nicole M. A. Huysmans, Marie-Charlotte D. N. J. M. van Leeuwen, Stephanie J. M. Thomas, Renske Z. |
author_sort | Bulthuis, Marjolein S. |
collection | PubMed |
description | OBJECTIVE: The aim of the present systematic review is to assess the prevalence and severity of and distress caused by xerostomia over time in adult hematopoietic stem cell transplantation (HSCT) recipients. METHODS: PubMed, Embase, and the Cochrane Library were searched for papers published between January 2000 and May 2022. Clinical studies were included if patient-reported subjective oral dryness was reported in adult autologous or allogeneic HSCT recipients. Risk of bias was assessed according to a quality grading strategy published by the oral care study group of the MASCC/ISOO, resulting in a score between 0 (highest risk of bias) and 10 (lowest risk of bias). Separate analysis focused on autologous HSCT recipients, allogeneic HSCT recipients receiving a myeloablative conditioning (MAC), and those receiving a reduced intensity conditioning (RIC). RESULTS: Searches yielded 1792 unique records; 22 studies met the inclusion criteria. The quality scores ranged between 1 and 7, with a median score of 4. The prevalence, severity, and distress of xerostomia increased shortly after HSCT. Severity of xerostomia in allogeneic MAC recipients was higher compared to allogeneic RIC recipients 2–5 months post-HSCT (mean difference: 18 points on 0–100 scale, 95% CI: 9–27); after 1–2 years, there was no significant difference anymore. CONCLUSION: The prevalence of xerostomia in HSCT recipients is high in comparison to the general population. The severity of complaints is raised during the first year post-HSCT. The intensity of the conditioning plays a key role in the short-term development of xerostomia, while factors affecting the recovery in the long term remain largely unknown. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00520-023-07921-1. |
format | Online Article Text |
id | pubmed-10329604 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-103296042023-07-10 The effect of hematopoietic stem cell transplantation on patient-reported subjective oral dryness: a systematic review focusing on prevalence, severity and distress Bulthuis, Marjolein S. van Gennip, Lucky L. A. Bronkhorst, Ewald M. Blijlevens, Nicole M. A. Huysmans, Marie-Charlotte D. N. J. M. van Leeuwen, Stephanie J. M. Thomas, Renske Z. Support Care Cancer Review OBJECTIVE: The aim of the present systematic review is to assess the prevalence and severity of and distress caused by xerostomia over time in adult hematopoietic stem cell transplantation (HSCT) recipients. METHODS: PubMed, Embase, and the Cochrane Library were searched for papers published between January 2000 and May 2022. Clinical studies were included if patient-reported subjective oral dryness was reported in adult autologous or allogeneic HSCT recipients. Risk of bias was assessed according to a quality grading strategy published by the oral care study group of the MASCC/ISOO, resulting in a score between 0 (highest risk of bias) and 10 (lowest risk of bias). Separate analysis focused on autologous HSCT recipients, allogeneic HSCT recipients receiving a myeloablative conditioning (MAC), and those receiving a reduced intensity conditioning (RIC). RESULTS: Searches yielded 1792 unique records; 22 studies met the inclusion criteria. The quality scores ranged between 1 and 7, with a median score of 4. The prevalence, severity, and distress of xerostomia increased shortly after HSCT. Severity of xerostomia in allogeneic MAC recipients was higher compared to allogeneic RIC recipients 2–5 months post-HSCT (mean difference: 18 points on 0–100 scale, 95% CI: 9–27); after 1–2 years, there was no significant difference anymore. CONCLUSION: The prevalence of xerostomia in HSCT recipients is high in comparison to the general population. The severity of complaints is raised during the first year post-HSCT. The intensity of the conditioning plays a key role in the short-term development of xerostomia, while factors affecting the recovery in the long term remain largely unknown. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00520-023-07921-1. Springer Berlin Heidelberg 2023-07-08 2023 /pmc/articles/PMC10329604/ /pubmed/37421511 http://dx.doi.org/10.1007/s00520-023-07921-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Bulthuis, Marjolein S. van Gennip, Lucky L. A. Bronkhorst, Ewald M. Blijlevens, Nicole M. A. Huysmans, Marie-Charlotte D. N. J. M. van Leeuwen, Stephanie J. M. Thomas, Renske Z. The effect of hematopoietic stem cell transplantation on patient-reported subjective oral dryness: a systematic review focusing on prevalence, severity and distress |
title | The effect of hematopoietic stem cell transplantation on patient-reported subjective oral dryness: a systematic review focusing on prevalence, severity and distress |
title_full | The effect of hematopoietic stem cell transplantation on patient-reported subjective oral dryness: a systematic review focusing on prevalence, severity and distress |
title_fullStr | The effect of hematopoietic stem cell transplantation on patient-reported subjective oral dryness: a systematic review focusing on prevalence, severity and distress |
title_full_unstemmed | The effect of hematopoietic stem cell transplantation on patient-reported subjective oral dryness: a systematic review focusing on prevalence, severity and distress |
title_short | The effect of hematopoietic stem cell transplantation on patient-reported subjective oral dryness: a systematic review focusing on prevalence, severity and distress |
title_sort | effect of hematopoietic stem cell transplantation on patient-reported subjective oral dryness: a systematic review focusing on prevalence, severity and distress |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10329604/ https://www.ncbi.nlm.nih.gov/pubmed/37421511 http://dx.doi.org/10.1007/s00520-023-07921-1 |
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