Proteome wide association studies of LRRK2 variants identify novel causal and druggable proteins for Parkinson’s disease

Common and rare variants in the LRRK2 locus are associated with Parkinson’s disease (PD) risk, but the downstream effects of these variants on protein levels remain unknown. We performed comprehensive proteogenomic analyses using the largest aptamer-based CSF proteomics study to date (7006 aptamers...

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Detalles Bibliográficos
Autores principales: Phillips, Bridget, Western, Daniel, Wang, Lihua, Timsina, Jigyasha, Sun, Yichen, Gorijala, Priyanka, Yang, Chengran, Do, Anh, Nykänen, Niko-Petteri, Alvarez, Ignacio, Aguilar, Miquel, Pastor, Pau, Morris, John C., Schindler, Suzanne E., Fagan, Anne M., Puerta, Raquel, García-González, Pablo, de Rojas, Itziar, Marquié, Marta, Boada, Mercè, Ruiz, Agustin, Perlmutter, Joel S., Ibanez, Laura, Perrin, Richard J., Sung, Yun Ju, Cruchaga, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10329646/
https://www.ncbi.nlm.nih.gov/pubmed/37422510
http://dx.doi.org/10.1038/s41531-023-00555-4

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