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Aging-related aneuploidy is associated with mitochondrial imbalance and failure of spindle assembly

Despite aging is closely linked to increased aneuploidy in the oocytes, the mechanism of how aging affects aneuploidy remains largely elusive. Here, we applied single-cell parallel methylation and transcriptome sequencing (scM&T-seq) data from the aging mouse oocyte model to decode the genomic l...

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Detalles Bibliográficos
Autores principales:	Zhang, Fa-Li, Li, Wei-Dong, Zhu, Ke-Xin, Zhou, Xu, Li, Lan, Lee, Tin-Lap, Shen, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10329675/ https://www.ncbi.nlm.nih.gov/pubmed/37422452 http://dx.doi.org/10.1038/s41420-023-01539-2

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