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Crosstalk between autophagy and CSCs: molecular mechanisms and translational implications
Cancer stem cells(CSCs) play a key role in regulating tumorigenesis, progression, as well as recurrence, and possess typical metabolic characteristics. Autophagy is a catabolic process that can aid cells to survive under stressful conditions such as nutrient deficiency and hypoxia. Although the role...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10329683/ https://www.ncbi.nlm.nih.gov/pubmed/37422448 http://dx.doi.org/10.1038/s41419-023-05929-3 |
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author | Li, Dai Peng, Xueqiang He, Guangpeng Liu, Jiaxing Li, Xian Lin, Weikai Fang, Jianjun Li, Xinyu Yang, Shuo Yang, Liang Li, Hangyu |
author_facet | Li, Dai Peng, Xueqiang He, Guangpeng Liu, Jiaxing Li, Xian Lin, Weikai Fang, Jianjun Li, Xinyu Yang, Shuo Yang, Liang Li, Hangyu |
author_sort | Li, Dai |
collection | PubMed |
description | Cancer stem cells(CSCs) play a key role in regulating tumorigenesis, progression, as well as recurrence, and possess typical metabolic characteristics. Autophagy is a catabolic process that can aid cells to survive under stressful conditions such as nutrient deficiency and hypoxia. Although the role of autophagy in cancer cells has been extensively studied, CSCs possess unique stemness, and their potential relationship with autophagy has not been fully analyzed. This study summarizes the possible role of autophagy in the renewal, proliferation, differentiation, survival, metastasis, invasion, and treatment resistance of CSCs. It has been found that autophagy can contribute to the maintenance of CSC stemness, facilitate the tumor cells adapt to changes in the microenvironment, and promote tumor survival, whereas in some other cases autophagy acts as an important process involved in the deprivation of CSC stemness thus leading to tumor death. Mitophagy, which has emerged as another popular research area in recent years, has a great scope when explored together with stem cells. In this study, we have aimed to elaborate on the mechanism of action of autophagy in regulating the functions of CSCs to provide deeper insights for future cancer treatment. |
format | Online Article Text |
id | pubmed-10329683 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-103296832023-07-10 Crosstalk between autophagy and CSCs: molecular mechanisms and translational implications Li, Dai Peng, Xueqiang He, Guangpeng Liu, Jiaxing Li, Xian Lin, Weikai Fang, Jianjun Li, Xinyu Yang, Shuo Yang, Liang Li, Hangyu Cell Death Dis Review Article Cancer stem cells(CSCs) play a key role in regulating tumorigenesis, progression, as well as recurrence, and possess typical metabolic characteristics. Autophagy is a catabolic process that can aid cells to survive under stressful conditions such as nutrient deficiency and hypoxia. Although the role of autophagy in cancer cells has been extensively studied, CSCs possess unique stemness, and their potential relationship with autophagy has not been fully analyzed. This study summarizes the possible role of autophagy in the renewal, proliferation, differentiation, survival, metastasis, invasion, and treatment resistance of CSCs. It has been found that autophagy can contribute to the maintenance of CSC stemness, facilitate the tumor cells adapt to changes in the microenvironment, and promote tumor survival, whereas in some other cases autophagy acts as an important process involved in the deprivation of CSC stemness thus leading to tumor death. Mitophagy, which has emerged as another popular research area in recent years, has a great scope when explored together with stem cells. In this study, we have aimed to elaborate on the mechanism of action of autophagy in regulating the functions of CSCs to provide deeper insights for future cancer treatment. Nature Publishing Group UK 2023-07-08 /pmc/articles/PMC10329683/ /pubmed/37422448 http://dx.doi.org/10.1038/s41419-023-05929-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Article Li, Dai Peng, Xueqiang He, Guangpeng Liu, Jiaxing Li, Xian Lin, Weikai Fang, Jianjun Li, Xinyu Yang, Shuo Yang, Liang Li, Hangyu Crosstalk between autophagy and CSCs: molecular mechanisms and translational implications |
title | Crosstalk between autophagy and CSCs: molecular mechanisms and translational implications |
title_full | Crosstalk between autophagy and CSCs: molecular mechanisms and translational implications |
title_fullStr | Crosstalk between autophagy and CSCs: molecular mechanisms and translational implications |
title_full_unstemmed | Crosstalk between autophagy and CSCs: molecular mechanisms and translational implications |
title_short | Crosstalk between autophagy and CSCs: molecular mechanisms and translational implications |
title_sort | crosstalk between autophagy and cscs: molecular mechanisms and translational implications |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10329683/ https://www.ncbi.nlm.nih.gov/pubmed/37422448 http://dx.doi.org/10.1038/s41419-023-05929-3 |
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