Effects of altered glycolysis levels on CD8(+) T cell activation and function

CD8(+) T cells are an important component of the body’s adaptive immune response. During viral or intracellular bacterial infections, CD8(+) T cells are rapidly activated and differentiated to exert their immune function by producing cytokines. Alterations in the glycolysis of CD8(+) T cells have an important effect on their activation and function, while glycolysis is important for CD8(+) T cell functional failure and recovery. This paper summarizes the importance of CD8(+) T cell glycolysis in the immune system. We discuss the link between glycolysis and CD8(+) T cell activation, differentiation, and proliferation, and the effect of altered glycolysis on CD8(+) T cell function. In addition, potential molecular targets to enhance and restore the immune function of CD8(+) T cells by affecting glycolysis and the link between glycolysis and CD8(+) T cell senescence are summarized. This review provides new insights into the relationship between glycolysis and CD8(+) T cell function, and proposes novel strategies for immunotherapy by targeting glycolysis.