Arteriovenous malformation Map2k1 mutation affects vasculogenesis

Somatic activating MAP2K1 mutations in endothelial cells (ECs) cause extracranial arteriovenous malformation (AVM). We previously reported the generation of a mouse line allowing inducible expression of constitutively active MAP2K1 (p.K57N) from the Rosa locus (R26(GT-Map2k1-GFP/+)) and showed, usin...

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Detalles Bibliográficos
Autores principales: Sudduth, Christopher L., Smits, Patrick J., Vivero, Matthew P., Cheng, Yu Sheng, Ad, Michal, Konczyk, Dennis J., Bischoff, Joyce, Warman, Matthew L., Greene, Arin K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10329712/
https://www.ncbi.nlm.nih.gov/pubmed/37422456
http://dx.doi.org/10.1038/s41598-023-35301-6

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