Cargando…
A prospective study of the prostate health index density and multiparametric magnetic resonance imaging in diagnosing clinically significant prostate cancer
PURPOSE: To evaluate the predictive performance of the prostate health index (PHI) and PHI density (PHID), for clinically significant prostate cancer (csPCa) in patients with a PI-RADS score ≤3. MATERIALS AND METHODS: Patients tested for total prostate-specific antigen (tPSA, ≤100 ng/mL), free PSA (...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Urological Association
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10330413/ https://www.ncbi.nlm.nih.gov/pubmed/37417561 http://dx.doi.org/10.4111/icu.20230060 |
_version_ | 1785070138541735936 |
---|---|
author | Chen, Yuanchong Xu, Dong Ruan, Mingjian Li, Haixia Lin, Guiting Song, Gang |
author_facet | Chen, Yuanchong Xu, Dong Ruan, Mingjian Li, Haixia Lin, Guiting Song, Gang |
author_sort | Chen, Yuanchong |
collection | PubMed |
description | PURPOSE: To evaluate the predictive performance of the prostate health index (PHI) and PHI density (PHID), for clinically significant prostate cancer (csPCa) in patients with a PI-RADS score ≤3. MATERIALS AND METHODS: Patients tested for total prostate-specific antigen (tPSA, ≤100 ng/mL), free PSA (fPSA), and p2PSA at Peking University First Hospital were prospectively enrolled. Possible predictive factors of csPCa were analyzed using the receiver operating characteristic (ROC) curve. Results were expressed as area under the curve (AUC) with 95% confidence intervals (CI). The cutoff values of PHI and PHID were determined. RESULTS: We enrolled 222 patients in this study. The prevalence of csPCa in the PI-RADS ≤3 subgroup (n=89) was 22.47% (20/89). Age, tPSA, F/T, prostate volume, PSA density, PHI, PHID, and PI-RADS score were significantly associated with csPCa. PHID (AUC: 0.829 [95% CI: 0.717–0.941]) was the best predictor of csPCa. PHID >0.956 was set as the threshold of suspicious csPCa with a sensitivity of 85.00% and a specificity of 73.91%, avoiding 94.44% of unnecessary biopsies but missing 15.00% csPCa. A threshold of PHI ≥52.83 showed the same sensitivity but a rather lower specificity of 65.22% that avoided 93.75% of unnecessary biopsies. CONCLUSIONS: PHI and PHID have the best predictive performance of csPCa in patients with PI-RADS score ≤3. A threshold value of PHID ≥0.956 may be used as the criterion for biopsy in these patients. |
format | Online Article Text |
id | pubmed-10330413 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The Korean Urological Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-103304132023-07-11 A prospective study of the prostate health index density and multiparametric magnetic resonance imaging in diagnosing clinically significant prostate cancer Chen, Yuanchong Xu, Dong Ruan, Mingjian Li, Haixia Lin, Guiting Song, Gang Investig Clin Urol Original Article PURPOSE: To evaluate the predictive performance of the prostate health index (PHI) and PHI density (PHID), for clinically significant prostate cancer (csPCa) in patients with a PI-RADS score ≤3. MATERIALS AND METHODS: Patients tested for total prostate-specific antigen (tPSA, ≤100 ng/mL), free PSA (fPSA), and p2PSA at Peking University First Hospital were prospectively enrolled. Possible predictive factors of csPCa were analyzed using the receiver operating characteristic (ROC) curve. Results were expressed as area under the curve (AUC) with 95% confidence intervals (CI). The cutoff values of PHI and PHID were determined. RESULTS: We enrolled 222 patients in this study. The prevalence of csPCa in the PI-RADS ≤3 subgroup (n=89) was 22.47% (20/89). Age, tPSA, F/T, prostate volume, PSA density, PHI, PHID, and PI-RADS score were significantly associated with csPCa. PHID (AUC: 0.829 [95% CI: 0.717–0.941]) was the best predictor of csPCa. PHID >0.956 was set as the threshold of suspicious csPCa with a sensitivity of 85.00% and a specificity of 73.91%, avoiding 94.44% of unnecessary biopsies but missing 15.00% csPCa. A threshold of PHI ≥52.83 showed the same sensitivity but a rather lower specificity of 65.22% that avoided 93.75% of unnecessary biopsies. CONCLUSIONS: PHI and PHID have the best predictive performance of csPCa in patients with PI-RADS score ≤3. A threshold value of PHID ≥0.956 may be used as the criterion for biopsy in these patients. The Korean Urological Association 2023-07 2023-06-15 /pmc/articles/PMC10330413/ /pubmed/37417561 http://dx.doi.org/10.4111/icu.20230060 Text en © The Korean Urological Association https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Chen, Yuanchong Xu, Dong Ruan, Mingjian Li, Haixia Lin, Guiting Song, Gang A prospective study of the prostate health index density and multiparametric magnetic resonance imaging in diagnosing clinically significant prostate cancer |
title | A prospective study of the prostate health index density and multiparametric magnetic resonance imaging in diagnosing clinically significant prostate cancer |
title_full | A prospective study of the prostate health index density and multiparametric magnetic resonance imaging in diagnosing clinically significant prostate cancer |
title_fullStr | A prospective study of the prostate health index density and multiparametric magnetic resonance imaging in diagnosing clinically significant prostate cancer |
title_full_unstemmed | A prospective study of the prostate health index density and multiparametric magnetic resonance imaging in diagnosing clinically significant prostate cancer |
title_short | A prospective study of the prostate health index density and multiparametric magnetic resonance imaging in diagnosing clinically significant prostate cancer |
title_sort | prospective study of the prostate health index density and multiparametric magnetic resonance imaging in diagnosing clinically significant prostate cancer |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10330413/ https://www.ncbi.nlm.nih.gov/pubmed/37417561 http://dx.doi.org/10.4111/icu.20230060 |
work_keys_str_mv | AT chenyuanchong aprospectivestudyoftheprostatehealthindexdensityandmultiparametricmagneticresonanceimagingindiagnosingclinicallysignificantprostatecancer AT xudong aprospectivestudyoftheprostatehealthindexdensityandmultiparametricmagneticresonanceimagingindiagnosingclinicallysignificantprostatecancer AT ruanmingjian aprospectivestudyoftheprostatehealthindexdensityandmultiparametricmagneticresonanceimagingindiagnosingclinicallysignificantprostatecancer AT lihaixia aprospectivestudyoftheprostatehealthindexdensityandmultiparametricmagneticresonanceimagingindiagnosingclinicallysignificantprostatecancer AT linguiting aprospectivestudyoftheprostatehealthindexdensityandmultiparametricmagneticresonanceimagingindiagnosingclinicallysignificantprostatecancer AT songgang aprospectivestudyoftheprostatehealthindexdensityandmultiparametricmagneticresonanceimagingindiagnosingclinicallysignificantprostatecancer AT chenyuanchong prospectivestudyoftheprostatehealthindexdensityandmultiparametricmagneticresonanceimagingindiagnosingclinicallysignificantprostatecancer AT xudong prospectivestudyoftheprostatehealthindexdensityandmultiparametricmagneticresonanceimagingindiagnosingclinicallysignificantprostatecancer AT ruanmingjian prospectivestudyoftheprostatehealthindexdensityandmultiparametricmagneticresonanceimagingindiagnosingclinicallysignificantprostatecancer AT lihaixia prospectivestudyoftheprostatehealthindexdensityandmultiparametricmagneticresonanceimagingindiagnosingclinicallysignificantprostatecancer AT linguiting prospectivestudyoftheprostatehealthindexdensityandmultiparametricmagneticresonanceimagingindiagnosingclinicallysignificantprostatecancer AT songgang prospectivestudyoftheprostatehealthindexdensityandmultiparametricmagneticresonanceimagingindiagnosingclinicallysignificantprostatecancer |