Cargando…
Quality of life in patients with transcatheter aortic valve implantation: an analysis from the INTERVENT project
BACKGROUND: Transcatheter aortic valve implantation (TAVI) is a standard treatment for patients with aortic valve stenosis due to its very low mortality and complication rates. However, survival and physical integrity are not the only important factors. Quality of life (QoL) improvement is a crucial...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10330696/ https://www.ncbi.nlm.nih.gov/pubmed/37435055 http://dx.doi.org/10.3389/fcvm.2023.1181771 |
_version_ | 1785070141693755392 |
---|---|
author | Tamm, Alexander R. Jobst, Marina L. Geyer, Martin Hahad, Omar Buderus, Victoria Schmidt, Alexander Prochaska, Jürgen H. Wild, Philipp S. Treede, Hendrik Münzel, Thomas von Bardeleben, Ralph Stephan |
author_facet | Tamm, Alexander R. Jobst, Marina L. Geyer, Martin Hahad, Omar Buderus, Victoria Schmidt, Alexander Prochaska, Jürgen H. Wild, Philipp S. Treede, Hendrik Münzel, Thomas von Bardeleben, Ralph Stephan |
author_sort | Tamm, Alexander R. |
collection | PubMed |
description | BACKGROUND: Transcatheter aortic valve implantation (TAVI) is a standard treatment for patients with aortic valve stenosis due to its very low mortality and complication rates. However, survival and physical integrity are not the only important factors. Quality of life (QoL) improvement is a crucial part in the evaluation of therapy success. METHODS: Patients with TAVI were questioned about their QoL before, one month and one year after the intervention as part of the INTERVENT registry trial at Mainz University Medical Center. Three different questionnaires were included in the data collection (Katz ADL, EQ-5D-5l, PHQ-D). RESULTS: We included 285 TAVI patients in the analysis (mean age 79.8 years, 59.4% male, mean EuroSCORE II 3.8%). 30-day mortality was 3.6%, complications of any kind occurred in 18.9% of the patients. Main finding was a significant increase in the general state of health measured on the visual analog scale by an average of 4.53 (± 23.58) points (BL to 1-month follow-up, p = 0.009) and by 5.19 (± 23.64) points (BL to 12-month follow-up, p = 0.016). There was also an improvement of depression symptoms, which was reflected in a decrease in the total value of the PHQ-D by 1.67 (± 4.75) points (BL to 12-month follow-up, p = 0.001). The evaluation of the EQ-5D-5l showed a significant improvement in mobility after one month (M = −0.41 (± 1.31), p < 0.001. Regarding the independence of the patients, no significant difference could be found. Apart from that, patients with risk factors, comorbidities or complications also benefited from the intervention despite their poor starting position. CONCLUSION: We could show an early benefit of QoL in TAVI patients with significant improvement in the subjective state of health and a decrease in symptoms of depression. These findings were consistent over 1 year of follow up. |
format | Online Article Text |
id | pubmed-10330696 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103306962023-07-11 Quality of life in patients with transcatheter aortic valve implantation: an analysis from the INTERVENT project Tamm, Alexander R. Jobst, Marina L. Geyer, Martin Hahad, Omar Buderus, Victoria Schmidt, Alexander Prochaska, Jürgen H. Wild, Philipp S. Treede, Hendrik Münzel, Thomas von Bardeleben, Ralph Stephan Front Cardiovasc Med Cardiovascular Medicine BACKGROUND: Transcatheter aortic valve implantation (TAVI) is a standard treatment for patients with aortic valve stenosis due to its very low mortality and complication rates. However, survival and physical integrity are not the only important factors. Quality of life (QoL) improvement is a crucial part in the evaluation of therapy success. METHODS: Patients with TAVI were questioned about their QoL before, one month and one year after the intervention as part of the INTERVENT registry trial at Mainz University Medical Center. Three different questionnaires were included in the data collection (Katz ADL, EQ-5D-5l, PHQ-D). RESULTS: We included 285 TAVI patients in the analysis (mean age 79.8 years, 59.4% male, mean EuroSCORE II 3.8%). 30-day mortality was 3.6%, complications of any kind occurred in 18.9% of the patients. Main finding was a significant increase in the general state of health measured on the visual analog scale by an average of 4.53 (± 23.58) points (BL to 1-month follow-up, p = 0.009) and by 5.19 (± 23.64) points (BL to 12-month follow-up, p = 0.016). There was also an improvement of depression symptoms, which was reflected in a decrease in the total value of the PHQ-D by 1.67 (± 4.75) points (BL to 12-month follow-up, p = 0.001). The evaluation of the EQ-5D-5l showed a significant improvement in mobility after one month (M = −0.41 (± 1.31), p < 0.001. Regarding the independence of the patients, no significant difference could be found. Apart from that, patients with risk factors, comorbidities or complications also benefited from the intervention despite their poor starting position. CONCLUSION: We could show an early benefit of QoL in TAVI patients with significant improvement in the subjective state of health and a decrease in symptoms of depression. These findings were consistent over 1 year of follow up. Frontiers Media S.A. 2023-06-26 /pmc/articles/PMC10330696/ /pubmed/37435055 http://dx.doi.org/10.3389/fcvm.2023.1181771 Text en © 2023 Tamm, Jobst, Geyer, Hahad, Buderus, Schmidt, Prochaska, Wild, Treede, Münzel and von Bardeleben. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cardiovascular Medicine Tamm, Alexander R. Jobst, Marina L. Geyer, Martin Hahad, Omar Buderus, Victoria Schmidt, Alexander Prochaska, Jürgen H. Wild, Philipp S. Treede, Hendrik Münzel, Thomas von Bardeleben, Ralph Stephan Quality of life in patients with transcatheter aortic valve implantation: an analysis from the INTERVENT project |
title | Quality of life in patients with transcatheter aortic valve implantation: an analysis from the INTERVENT project |
title_full | Quality of life in patients with transcatheter aortic valve implantation: an analysis from the INTERVENT project |
title_fullStr | Quality of life in patients with transcatheter aortic valve implantation: an analysis from the INTERVENT project |
title_full_unstemmed | Quality of life in patients with transcatheter aortic valve implantation: an analysis from the INTERVENT project |
title_short | Quality of life in patients with transcatheter aortic valve implantation: an analysis from the INTERVENT project |
title_sort | quality of life in patients with transcatheter aortic valve implantation: an analysis from the intervent project |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10330696/ https://www.ncbi.nlm.nih.gov/pubmed/37435055 http://dx.doi.org/10.3389/fcvm.2023.1181771 |
work_keys_str_mv | AT tammalexanderr qualityoflifeinpatientswithtranscatheteraorticvalveimplantationananalysisfromtheinterventproject AT jobstmarinal qualityoflifeinpatientswithtranscatheteraorticvalveimplantationananalysisfromtheinterventproject AT geyermartin qualityoflifeinpatientswithtranscatheteraorticvalveimplantationananalysisfromtheinterventproject AT hahadomar qualityoflifeinpatientswithtranscatheteraorticvalveimplantationananalysisfromtheinterventproject AT buderusvictoria qualityoflifeinpatientswithtranscatheteraorticvalveimplantationananalysisfromtheinterventproject AT schmidtalexander qualityoflifeinpatientswithtranscatheteraorticvalveimplantationananalysisfromtheinterventproject AT prochaskajurgenh qualityoflifeinpatientswithtranscatheteraorticvalveimplantationananalysisfromtheinterventproject AT wildphilipps qualityoflifeinpatientswithtranscatheteraorticvalveimplantationananalysisfromtheinterventproject AT treedehendrik qualityoflifeinpatientswithtranscatheteraorticvalveimplantationananalysisfromtheinterventproject AT munzelthomas qualityoflifeinpatientswithtranscatheteraorticvalveimplantationananalysisfromtheinterventproject AT vonbardelebenralphstephan qualityoflifeinpatientswithtranscatheteraorticvalveimplantationananalysisfromtheinterventproject |