Antigen presentation by clonally diverse CXCR5+ B cells to CD4 and CD8 T cells is associated with durable response to immune checkpoint inhibitors

INTRODUCTION: Increased T cell infiltration and interferon gamma (IFNγ) pathway activation are seen in tumors of melanoma patients who respond to ICI (immune checkpoint inhibitor) or MAPK pathway inhibitor (MAPKi) therapies. Yet, the rate of durable tumor control after ICI is almost twice that of MA...

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Detalles Bibliográficos
Autores principales: Ding, Lizhong, Sun, Lu, Bu, Melissa T., Zhang, Yanjun, Scott, Lauren N., Prins, Robert M., Su, Maureen A., Lechner, Melissa G., Hugo, Willy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10330698/
https://www.ncbi.nlm.nih.gov/pubmed/37435085
http://dx.doi.org/10.3389/fimmu.2023.1176994

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10330698/
https://www.ncbi.nlm.nih.gov/pubmed/37435085
http://dx.doi.org/10.3389/fimmu.2023.1176994

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