Cargando…

Antigen presentation by clonally diverse CXCR5+ B cells to CD4 and CD8 T cells is associated with durable response to immune checkpoint inhibitors

INTRODUCTION: Increased T cell infiltration and interferon gamma (IFNγ) pathway activation are seen in tumors of melanoma patients who respond to ICI (immune checkpoint inhibitor) or MAPK pathway inhibitor (MAPKi) therapies. Yet, the rate of durable tumor control after ICI is almost twice that of MA...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ding, Lizhong, Sun, Lu, Bu, Melissa T., Zhang, Yanjun, Scott, Lauren N., Prins, Robert M., Su, Maureen A., Lechner, Melissa G., Hugo, Willy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10330698/ https://www.ncbi.nlm.nih.gov/pubmed/37435085 http://dx.doi.org/10.3389/fimmu.2023.1176994

Ejemplares similares

Clonal expansion of CD8(+) T cells reflects graft-versus-leukemia activity and precedes durable remission following DLI
por: Schultze-Florey, Christian R., et al.
Publicado: (2021)

Peripheral CD8+ T cell characteristics associated with durable responses to immune checkpoint blockade in patients with metastatic melanoma
por: Fairfax, Benjamin P, et al.
Publicado: (2020)

CXCR5+ CD8 T Cells: Protective or Pathogenic?
por: Valentine, Kristen M., et al.
Publicado: (2019)

Inflammation durably imprints memory CD4+ T cells
por: Gray-Gaillard, Sophie L., et al.
Publicado: (2023)

CD271+, CXCR7+, CXCR4+, and CD133+ Stem/Progenitor Cells and Clinical Characteristics of Acute Ischemic Stroke Patients
por: Gójska-Grymajło, Anna, et al.
Publicado: (2018)

Avidity for antigen shapes clonal dominance in CD8(+) T cell populations specific for persistent DNA viruses
por: Price, David A., et al.
Publicado: (2005)

Distinct Roles for CXCR6(+) and CXCR6(−) CD4(+) T Cells in the Pathogenesis of Chronic Colitis
por: Mandai, Yasushi, et al.
Publicado: (2013)

Expression of a functional CD3-Ti antigen/MHC receptor in the absence of surface CD2. Analysis with clonal Jurkat cell mutants
Publicado: (1988)

Enriched CXCR3(+) CXCR5(+) CD8(+) T cells in SARS-CoV-2 infected and vaccinated individuals effectively respond to the antigen in recall
por: Zhou, Pengcheng, et al.
Publicado: (2023)

Select sequencing of clonally expanded CD8(+) T cells reveals limits to clonal expansion
por: Huang, Huang, et al.
Publicado: (2019)

Clonality of CD4(+) Blood T Cells Predicts Longer Survival With CTLA4 or PD-1 Checkpoint Inhibition in Advanced Melanoma
por: Arakawa, Akiko, et al.
Publicado: (2019)

A case report of clonal EBV-like memory CD4+ T cell activation in fatal checkpoint inhibitor-induced encephalitis
por: Johnson, Douglas B., et al.
Publicado: (2019)

Isolation of CD133+ Liver Stem Cells for Clonal Expansion
por: Rountree, C. Bart, et al.
Publicado: (2011)

CD40-Activated B Cells Can Efficiently Prime Antigen-Specific Naïve CD8(+) T Cells to Generate Effector but Not Memory T cells
por: Mathieu, Mélissa, et al.
Publicado: (2012)

Improved Functionality of Exhausted Intrahepatic CXCR5+ CD8+ T Cells Contributes to Chronic Antigen Clearance Upon Immunomodulation
por: Kumashie, Kingsley Gideon, et al.
Publicado: (2021)

Clonality of HTLV-1 differs between infected CD8+ T cells and infected CD4+ T cells in vivo
por: Melamed, Anat, et al.
Publicado: (2014)

CD8(+)CXCR5(+) T Cells Regulate Pathology in the Genital Tract
por: Jiang, Janina, et al.
Publicado: (2013)

CXCR6 is required for antitumor efficacy of intratumoral CD8(+) T cell
por: Wang, Binglin, et al.
Publicado: (2021)

Emerging Immune Checkpoint Molecules on Cancer Cells: CD24 and CD200
por: Moon, Sun Young, et al.
Publicado: (2023)

Clonal Structure of Rapid-Onset MDV-Driven CD4+ Lymphomas and Responding CD8+ T Cells
por: Mwangi, William N., et al.
Publicado: (2011)

Highly clonal regulatory T-cell population in follicular lymphoma – inverse correlation with the diversity of CD8(+) T cells
por: Liu, Xiao, et al.
Publicado: (2015)

Decreased levels of T follicular helper (CD4+CXCR5+) cells and CD27+CD38+ and CD27+CD38− B cells in ankylosing spondylitis patients correlate with markers of inflammation
por: Lejon, Kristina, et al.
Publicado: (2022)

Cholesterol-dependent plasma membrane order (L(o)) is critical for antigen-specific clonal expansion of CD4(+) T cells
por: Sengupta, Soumini, et al.
Publicado: (2021)

T cell receptor repertoire in polymyositis: clonal expansion of autoaggressive CD8+ T cells
Publicado: (1995)

Anti-tumor memory CD4 and CD8 T-cells quantified by bulk T-cell receptor (TCR) clonal analysis
por: Gao, Yanhua, et al.
Publicado: (2023)

Functional characterization of human Cd33(+ )And Cd11b(+ )myeloid-derived suppressor cell subsets induced from peripheral blood mononuclear cells co-cultured with a diverse set of human tumor cell lines
por: Lechner, Melissa G, et al.
Publicado: (2011)

Clonally diverse CD38(+)HLA-DR(+)CD8(+) T cells persist during fatal H7N9 disease
por: Wang, Zhongfang, et al.
Publicado: (2018)

Clonal analysis of functionally distinct human CD4+ T cell subsets
Publicado: (1988)

Clonal Expansion of Infected CD4+ T Cells in People Living with HIV
por: Coffin, John M., et al.
Publicado: (2021)

UTX promotes CD8(+) T cell-mediated antiviral defenses but reduces T cell durability
por: Mitchell, Joseph E., et al.
Publicado: (2021)

Immune Checkpoint Function of CD85j in CD8 T Cell Differentiation and Aging
por: Gustafson, Claire E., et al.
Publicado: (2017)

Reduced CD4(+)T Cell CXCR3 Expression in Patients With Allergic Rhinitis
por: Yu, Xiaofeng, et al.
Publicado: (2020)

The CXCL13/CXCR5-chemokine axis in neuroinflammation: evidence of CXCR5+CD4 T cell recruitment to CSF
por: Harrer, Christine, et al.
Publicado: (2021)

The Regulation between CD4(+)CXCR5(+) Follicular Helper T (Tfh) Cells and CD19(+)CD24(hi)CD38(hi) Regulatory B (Breg) Cells in Gastric Cancer
por: Zhang, Ying, et al.
Publicado: (2022)

Adjuvant-enhanced CD4 T Cell Responses are Critical to Durable Vaccine Immunity
por: Martins, Karen A.O., et al.
Publicado: (2015)

TCR repertoire profiling revealed antigen-driven CD8+ T cell clonal groups shared in synovial fluid of patients with spondyloarthritis
por: Komech, Ekaterina A., et al.
Publicado: (2022)

Narrowing the Gap: Preserving Repertoire Diversity Despite Clonal Selection during the CD4 T Cell Response
por: Merkenschlager, Julia, et al.
Publicado: (2015)

Tumor Infiltrating Effector Memory Antigen-Specific CD8(+) T Cells Predict Response to Immune Checkpoint Therapy
por: Principe, Nicola, et al.
Publicado: (2020)

Lipid raft-based membrane order is important for antigen-specific clonal expansion of CD4(+) T lymphocytes
por: Schieffer, Daniel, et al.
Publicado: (2014)

Mapping the Lineage Relationship between CXCR5(+) and CXCR5(−) CD4(+) T Cells in HIV-Infected Human Lymph Nodes
por: Del Alcazar, Daniel, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_31qm1hoijj7csjro107dg0vfke