Slipped-strand mispairing within a polycytidine tract in transcriptional regulator mga leads to M protein phase variation and Mga length polymorphism in Group A Streptococcus

The M protein, a major virulence factor of Group A Streptococcus (GAS), is regulated by the multigene regulator Mga. An unexplained phenomena frequently occurring with in vitro genetic manipulation or culturing of M1T1 GAS strains is the loss of M protein production. This study was aimed at elucidat...

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Detalles Bibliográficos
Autores principales: Lei, Benfang, Hanks, Tracey S., Bao, Yunjuan, Liu, Mengyao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10330708/
https://www.ncbi.nlm.nih.gov/pubmed/37434706
http://dx.doi.org/10.3389/fmicb.2023.1212149

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10330708/
https://www.ncbi.nlm.nih.gov/pubmed/37434706
http://dx.doi.org/10.3389/fmicb.2023.1212149

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