Cargando…

Original research: longitudinal evaluation of cognitively demanding daily function using performance-based functional assessment highlights heterogeneous trajectories in cognitive and functional abilities in people with Parkinson’s disease

BACKGROUND: Longitudinal assessment of functional abilities in Parkinson’s disease (PD) is needed to determine the efficacy of cognitive interventions in providing meaningful improvements in daily life. Additionally, subtle changes in instrumental activities of daily living may precede a clinical di...

Descripción completa

Detalles Bibliográficos
Autores principales: Carlisle, Tara C., Fought, Angela J., Olson, Kaitlin E., Lopez-Esquibel, Natalie, Simpson, Abigail, Medina, Luis D., Holden, Samantha K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10330725/
https://www.ncbi.nlm.nih.gov/pubmed/37434765
http://dx.doi.org/10.3389/fnins.2023.1200347
_version_ 1785070147671687168
author Carlisle, Tara C.
Fought, Angela J.
Olson, Kaitlin E.
Lopez-Esquibel, Natalie
Simpson, Abigail
Medina, Luis D.
Holden, Samantha K.
author_facet Carlisle, Tara C.
Fought, Angela J.
Olson, Kaitlin E.
Lopez-Esquibel, Natalie
Simpson, Abigail
Medina, Luis D.
Holden, Samantha K.
author_sort Carlisle, Tara C.
collection PubMed
description BACKGROUND: Longitudinal assessment of functional abilities in Parkinson’s disease (PD) is needed to determine the efficacy of cognitive interventions in providing meaningful improvements in daily life. Additionally, subtle changes in instrumental activities of daily living may precede a clinical diagnosis of dementia and could aid earlier detection of and intervention for cognitive decline. OBJECTIVE: The primary goal was to validate the longitudinal application of the University of California San Diego Performance-Based Skills Assessment (UPSA). An exploratory secondary goal was to determine whether UPSA may identify individuals at higher risk of cognitive decline in PD. METHODS: Seventy participants with PD completed the UPSA with at least one follow-up visit. Linear mixed effects modeling was used to identify associations between baseline UPSA score and cognitive composite score (CCS) over time. Descriptive analysis of four heterogeneous cognitive and functional trajectory groups and individual case examples was performed. RESULTS: Baseline UPSA score predicted CCS at each timepoint for functionally impaired and unimpaired groups (p < 0.01) but did not predict the rate change in CCS over time (p = 0.83). Participants displayed heterogenous trajectories in both UPSA and CCS during the follow-up period. Most participants maintained both cognitive and functional performance (n = 54), though some displayed cognitive and functional decline (n = 4), cognitive decline with functional maintenance (n = 4), and functional decline with cognitive maintenance (n = 8). CONCLUSION: The UPSA is a valid measure of cognitive functional abilities over time in PD. Given the heterogeneity of functional and cognitive trajectories, this performance-based assessment did not predict cognitive decline with this relatively short follow-up. Further work is needed to understand longitudinal functional assessments in PD-associated cognitive impairment.
format Online
Article
Text
id pubmed-10330725
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-103307252023-07-11 Original research: longitudinal evaluation of cognitively demanding daily function using performance-based functional assessment highlights heterogeneous trajectories in cognitive and functional abilities in people with Parkinson’s disease Carlisle, Tara C. Fought, Angela J. Olson, Kaitlin E. Lopez-Esquibel, Natalie Simpson, Abigail Medina, Luis D. Holden, Samantha K. Front Neurosci Neuroscience BACKGROUND: Longitudinal assessment of functional abilities in Parkinson’s disease (PD) is needed to determine the efficacy of cognitive interventions in providing meaningful improvements in daily life. Additionally, subtle changes in instrumental activities of daily living may precede a clinical diagnosis of dementia and could aid earlier detection of and intervention for cognitive decline. OBJECTIVE: The primary goal was to validate the longitudinal application of the University of California San Diego Performance-Based Skills Assessment (UPSA). An exploratory secondary goal was to determine whether UPSA may identify individuals at higher risk of cognitive decline in PD. METHODS: Seventy participants with PD completed the UPSA with at least one follow-up visit. Linear mixed effects modeling was used to identify associations between baseline UPSA score and cognitive composite score (CCS) over time. Descriptive analysis of four heterogeneous cognitive and functional trajectory groups and individual case examples was performed. RESULTS: Baseline UPSA score predicted CCS at each timepoint for functionally impaired and unimpaired groups (p < 0.01) but did not predict the rate change in CCS over time (p = 0.83). Participants displayed heterogenous trajectories in both UPSA and CCS during the follow-up period. Most participants maintained both cognitive and functional performance (n = 54), though some displayed cognitive and functional decline (n = 4), cognitive decline with functional maintenance (n = 4), and functional decline with cognitive maintenance (n = 8). CONCLUSION: The UPSA is a valid measure of cognitive functional abilities over time in PD. Given the heterogeneity of functional and cognitive trajectories, this performance-based assessment did not predict cognitive decline with this relatively short follow-up. Further work is needed to understand longitudinal functional assessments in PD-associated cognitive impairment. Frontiers Media S.A. 2023-06-26 /pmc/articles/PMC10330725/ /pubmed/37434765 http://dx.doi.org/10.3389/fnins.2023.1200347 Text en Copyright © 2023 Carlisle, Fought, Olson, Lopez-Esquibel, Simpson, Medina and Holden. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Carlisle, Tara C.
Fought, Angela J.
Olson, Kaitlin E.
Lopez-Esquibel, Natalie
Simpson, Abigail
Medina, Luis D.
Holden, Samantha K.
Original research: longitudinal evaluation of cognitively demanding daily function using performance-based functional assessment highlights heterogeneous trajectories in cognitive and functional abilities in people with Parkinson’s disease
title Original research: longitudinal evaluation of cognitively demanding daily function using performance-based functional assessment highlights heterogeneous trajectories in cognitive and functional abilities in people with Parkinson’s disease
title_full Original research: longitudinal evaluation of cognitively demanding daily function using performance-based functional assessment highlights heterogeneous trajectories in cognitive and functional abilities in people with Parkinson’s disease
title_fullStr Original research: longitudinal evaluation of cognitively demanding daily function using performance-based functional assessment highlights heterogeneous trajectories in cognitive and functional abilities in people with Parkinson’s disease
title_full_unstemmed Original research: longitudinal evaluation of cognitively demanding daily function using performance-based functional assessment highlights heterogeneous trajectories in cognitive and functional abilities in people with Parkinson’s disease
title_short Original research: longitudinal evaluation of cognitively demanding daily function using performance-based functional assessment highlights heterogeneous trajectories in cognitive and functional abilities in people with Parkinson’s disease
title_sort original research: longitudinal evaluation of cognitively demanding daily function using performance-based functional assessment highlights heterogeneous trajectories in cognitive and functional abilities in people with parkinson’s disease
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10330725/
https://www.ncbi.nlm.nih.gov/pubmed/37434765
http://dx.doi.org/10.3389/fnins.2023.1200347
work_keys_str_mv AT carlisletarac originalresearchlongitudinalevaluationofcognitivelydemandingdailyfunctionusingperformancebasedfunctionalassessmenthighlightsheterogeneoustrajectoriesincognitiveandfunctionalabilitiesinpeoplewithparkinsonsdisease
AT foughtangelaj originalresearchlongitudinalevaluationofcognitivelydemandingdailyfunctionusingperformancebasedfunctionalassessmenthighlightsheterogeneoustrajectoriesincognitiveandfunctionalabilitiesinpeoplewithparkinsonsdisease
AT olsonkaitline originalresearchlongitudinalevaluationofcognitivelydemandingdailyfunctionusingperformancebasedfunctionalassessmenthighlightsheterogeneoustrajectoriesincognitiveandfunctionalabilitiesinpeoplewithparkinsonsdisease
AT lopezesquibelnatalie originalresearchlongitudinalevaluationofcognitivelydemandingdailyfunctionusingperformancebasedfunctionalassessmenthighlightsheterogeneoustrajectoriesincognitiveandfunctionalabilitiesinpeoplewithparkinsonsdisease
AT simpsonabigail originalresearchlongitudinalevaluationofcognitivelydemandingdailyfunctionusingperformancebasedfunctionalassessmenthighlightsheterogeneoustrajectoriesincognitiveandfunctionalabilitiesinpeoplewithparkinsonsdisease
AT medinaluisd originalresearchlongitudinalevaluationofcognitivelydemandingdailyfunctionusingperformancebasedfunctionalassessmenthighlightsheterogeneoustrajectoriesincognitiveandfunctionalabilitiesinpeoplewithparkinsonsdisease
AT holdensamanthak originalresearchlongitudinalevaluationofcognitivelydemandingdailyfunctionusingperformancebasedfunctionalassessmenthighlightsheterogeneoustrajectoriesincognitiveandfunctionalabilitiesinpeoplewithparkinsonsdisease