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Biallelic disruption of DDX41 activity is associated with distinct genomic and immunophenotypic hallmarks in acute leukemia

INTRODUCTION: Inherited DDX41 mutations cause familial predisposition to hematologic malignancies including acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS), with the majority of DDX41 mutated MDS/AMLs described to date harboring germline DDX41 and co-occurring somatic DDX41 variants...

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Detalles Bibliográficos
Autores principales:	Tierens, Anne, Kagotho, Elizabeth, Shinriki, Satoru, Seto, Andrew, Smith, Adam C., Care, Melanie, Maze, Dawn, Sibai, Hassan, Yee, Karen W., Schuh, Andre C., Kim, Dennis Dong Hwan, Gupta, Vikas, Minden, Mark D., Matsui, Hirotaka, Capo-Chichi, José-Mario
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10331015/ https://www.ncbi.nlm.nih.gov/pubmed/37434984 http://dx.doi.org/10.3389/fonc.2023.1153082

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