Baicalein Inhibits α-Melanocyte-stimulating Hormone-stimulated Melanogenesis via p38 Mitogen-activated Protein Kinase Pathway in B16F10 Mouse Melanoma Cells

Excessive UVB exposure causes development of both malignant and non-malignant melanoma via the secretion of α-melanocyte-stimulating hormone (α-MSH). We investigated whether baicalein (5,6,7-trihydroxyflavone) could inhibit α-MSH-stimulated melanogenesis. Baicalein prevented UVB- and α-MSH-induced m...

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Autores principales: Oh, Min Chang, Fernando, Pincha Devage Sameera Madushan, Piao, Mei Jing, Kang, Kyoung Ah, Herath, Herath Mudiyanselage Udari lakmini, Hyun, Jin Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Cancer Prevention 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10331030/
https://www.ncbi.nlm.nih.gov/pubmed/37434796
http://dx.doi.org/10.15430/JCP.2023.28.2.40
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author Oh, Min Chang
Fernando, Pincha Devage Sameera Madushan
Piao, Mei Jing
Kang, Kyoung Ah
Herath, Herath Mudiyanselage Udari lakmini
Hyun, Jin Won
author_facet Oh, Min Chang
Fernando, Pincha Devage Sameera Madushan
Piao, Mei Jing
Kang, Kyoung Ah
Herath, Herath Mudiyanselage Udari lakmini
Hyun, Jin Won
author_sort Oh, Min Chang
collection PubMed
description Excessive UVB exposure causes development of both malignant and non-malignant melanoma via the secretion of α-melanocyte-stimulating hormone (α-MSH). We investigated whether baicalein (5,6,7-trihydroxyflavone) could inhibit α-MSH-stimulated melanogenesis. Baicalein prevented UVB- and α-MSH-induced melanin production and attenuated α-MSH-stimulated tyrosinase (monophenol monooxygenase) activity, and expression of tyrosinase and tyrosine-related protein-2. In addition, baicalein prevented melanogenesis and pigmentation via the p38 mitogen-activated protein kinases signaling pathway. These findings suggest that baicalein represents a natural compound for attenuating melanogenesis.
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spelling pubmed-103310302023-07-11 Baicalein Inhibits α-Melanocyte-stimulating Hormone-stimulated Melanogenesis via p38 Mitogen-activated Protein Kinase Pathway in B16F10 Mouse Melanoma Cells Oh, Min Chang Fernando, Pincha Devage Sameera Madushan Piao, Mei Jing Kang, Kyoung Ah Herath, Herath Mudiyanselage Udari lakmini Hyun, Jin Won J Cancer Prev Original Article Excessive UVB exposure causes development of both malignant and non-malignant melanoma via the secretion of α-melanocyte-stimulating hormone (α-MSH). We investigated whether baicalein (5,6,7-trihydroxyflavone) could inhibit α-MSH-stimulated melanogenesis. Baicalein prevented UVB- and α-MSH-induced melanin production and attenuated α-MSH-stimulated tyrosinase (monophenol monooxygenase) activity, and expression of tyrosinase and tyrosine-related protein-2. In addition, baicalein prevented melanogenesis and pigmentation via the p38 mitogen-activated protein kinases signaling pathway. These findings suggest that baicalein represents a natural compound for attenuating melanogenesis. Korean Society of Cancer Prevention 2023-06-30 2023-06-30 /pmc/articles/PMC10331030/ /pubmed/37434796 http://dx.doi.org/10.15430/JCP.2023.28.2.40 Text en Copyright © 2023 Korean Society of Cancer Prevention https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Oh, Min Chang
Fernando, Pincha Devage Sameera Madushan
Piao, Mei Jing
Kang, Kyoung Ah
Herath, Herath Mudiyanselage Udari lakmini
Hyun, Jin Won
Baicalein Inhibits α-Melanocyte-stimulating Hormone-stimulated Melanogenesis via p38 Mitogen-activated Protein Kinase Pathway in B16F10 Mouse Melanoma Cells
title Baicalein Inhibits α-Melanocyte-stimulating Hormone-stimulated Melanogenesis via p38 Mitogen-activated Protein Kinase Pathway in B16F10 Mouse Melanoma Cells
title_full Baicalein Inhibits α-Melanocyte-stimulating Hormone-stimulated Melanogenesis via p38 Mitogen-activated Protein Kinase Pathway in B16F10 Mouse Melanoma Cells
title_fullStr Baicalein Inhibits α-Melanocyte-stimulating Hormone-stimulated Melanogenesis via p38 Mitogen-activated Protein Kinase Pathway in B16F10 Mouse Melanoma Cells
title_full_unstemmed Baicalein Inhibits α-Melanocyte-stimulating Hormone-stimulated Melanogenesis via p38 Mitogen-activated Protein Kinase Pathway in B16F10 Mouse Melanoma Cells
title_short Baicalein Inhibits α-Melanocyte-stimulating Hormone-stimulated Melanogenesis via p38 Mitogen-activated Protein Kinase Pathway in B16F10 Mouse Melanoma Cells
title_sort baicalein inhibits α-melanocyte-stimulating hormone-stimulated melanogenesis via p38 mitogen-activated protein kinase pathway in b16f10 mouse melanoma cells
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10331030/
https://www.ncbi.nlm.nih.gov/pubmed/37434796
http://dx.doi.org/10.15430/JCP.2023.28.2.40
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