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Predicting the chemotherapeutic response of colorectal cancer liver metastasis using shear-wave elastography

PURPOSE: The aim of this study was to assess the role of the shear-wave velocity (SWV) value in predicting chemotherapeutic response and progression-free survival (PFS) in patients with colorectal cancer liver metastasis (CRLM). METHODS: In this prospective single-center study, participants with CRL...

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Autores principales: Bae, Jae Seok, Lee, Jae Young, Lee, Dong Ho, Han, Sae-Won, Lim, Yoojoo, Kim, Tae-You
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Ultrasound in Medicine 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10331051/
https://www.ncbi.nlm.nih.gov/pubmed/37345310
http://dx.doi.org/10.14366/usg.22214
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author Bae, Jae Seok
Lee, Jae Young
Lee, Dong Ho
Han, Sae-Won
Lim, Yoojoo
Kim, Tae-You
author_facet Bae, Jae Seok
Lee, Jae Young
Lee, Dong Ho
Han, Sae-Won
Lim, Yoojoo
Kim, Tae-You
author_sort Bae, Jae Seok
collection PubMed
description PURPOSE: The aim of this study was to assess the role of the shear-wave velocity (SWV) value in predicting chemotherapeutic response and progression-free survival (PFS) in patients with colorectal cancer liver metastasis (CRLM). METHODS: In this prospective single-center study, participants with CRLM scheduled for chemotherapy were enrolled between May 2018 and June 2021. SWV measurements were obtained using shear-wave elastography at the CRLM site before and after initiating chemotherapy. Based on the Response Evaluation Criteria in Solid Tumors, the participants were categorized by chemotherapeutic response into responders (complete remission and partial remission) and non-responders (stable disease and progressive disease). Receiver operating characteristic (ROC) curve analysis was conducted to evaluate the performance of changes in SWV measurements in predicting the chemotherapeutic response of CRLM. In addition, a Cox proportional hazards model was used to identify variables associated with PFS. RESULTS: In total, 67 participants (40 men; mean age, 62.3±10.1 years) were enrolled, including 34 responders and 33 non-responders. The area under the ROC curve, sensitivity, and negative predictive value of the SWV measurement in predicting non-responders were 0.840, 97.0%, and 95.2%, respectively, using a cutoff value of a 13% decrease. Additionally, a change in SWV values was independently associated with PFS (hazard ratio, 1.020), non-responder status, and the presence of five or more CRLMs. CONCLUSION: A change in SWV values measured after chemotherapy demonstrated meaningful diagnostic performance in predicting non-responsiveness among patients with CRLM. Additionally, a change in SWV values was independently associated with PFS.
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spelling pubmed-103310512023-07-11 Predicting the chemotherapeutic response of colorectal cancer liver metastasis using shear-wave elastography Bae, Jae Seok Lee, Jae Young Lee, Dong Ho Han, Sae-Won Lim, Yoojoo Kim, Tae-You Ultrasonography Original Article PURPOSE: The aim of this study was to assess the role of the shear-wave velocity (SWV) value in predicting chemotherapeutic response and progression-free survival (PFS) in patients with colorectal cancer liver metastasis (CRLM). METHODS: In this prospective single-center study, participants with CRLM scheduled for chemotherapy were enrolled between May 2018 and June 2021. SWV measurements were obtained using shear-wave elastography at the CRLM site before and after initiating chemotherapy. Based on the Response Evaluation Criteria in Solid Tumors, the participants were categorized by chemotherapeutic response into responders (complete remission and partial remission) and non-responders (stable disease and progressive disease). Receiver operating characteristic (ROC) curve analysis was conducted to evaluate the performance of changes in SWV measurements in predicting the chemotherapeutic response of CRLM. In addition, a Cox proportional hazards model was used to identify variables associated with PFS. RESULTS: In total, 67 participants (40 men; mean age, 62.3±10.1 years) were enrolled, including 34 responders and 33 non-responders. The area under the ROC curve, sensitivity, and negative predictive value of the SWV measurement in predicting non-responders were 0.840, 97.0%, and 95.2%, respectively, using a cutoff value of a 13% decrease. Additionally, a change in SWV values was independently associated with PFS (hazard ratio, 1.020), non-responder status, and the presence of five or more CRLMs. CONCLUSION: A change in SWV values measured after chemotherapy demonstrated meaningful diagnostic performance in predicting non-responsiveness among patients with CRLM. Additionally, a change in SWV values was independently associated with PFS. Korean Society of Ultrasound in Medicine 2023-07 2023-06-13 /pmc/articles/PMC10331051/ /pubmed/37345310 http://dx.doi.org/10.14366/usg.22214 Text en Copyright © 2023 Korean Society of Ultrasound in Medicine (KSUM) https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Bae, Jae Seok
Lee, Jae Young
Lee, Dong Ho
Han, Sae-Won
Lim, Yoojoo
Kim, Tae-You
Predicting the chemotherapeutic response of colorectal cancer liver metastasis using shear-wave elastography
title Predicting the chemotherapeutic response of colorectal cancer liver metastasis using shear-wave elastography
title_full Predicting the chemotherapeutic response of colorectal cancer liver metastasis using shear-wave elastography
title_fullStr Predicting the chemotherapeutic response of colorectal cancer liver metastasis using shear-wave elastography
title_full_unstemmed Predicting the chemotherapeutic response of colorectal cancer liver metastasis using shear-wave elastography
title_short Predicting the chemotherapeutic response of colorectal cancer liver metastasis using shear-wave elastography
title_sort predicting the chemotherapeutic response of colorectal cancer liver metastasis using shear-wave elastography
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10331051/
https://www.ncbi.nlm.nih.gov/pubmed/37345310
http://dx.doi.org/10.14366/usg.22214
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