Cargando…
Evaluation of diuretic efficiency of intravenous furosemide in patients with advanced heart failure in a heart failure clinic
INTRODUCTION: Diuretic efficiency (DE) is an independent predictor of all-cause mortality in acute heart failure (HF) at long-term follow-up. The performance of DE in advanced HF and the outpatient scenario is unclear. METHODS: Survival function analysis on a retrospective cohort of patients with ad...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10331187/ https://www.ncbi.nlm.nih.gov/pubmed/37417658 http://dx.doi.org/10.1177/17539447231184984 |
_version_ | 1785070206810324992 |
---|---|
author | Herrera-Leaño, Nancy Barahona-Correa, Julián E. Muñoz-Velandia, Oscar Fernández-Ávila, Daniel G. Mariño-Correa, Alejandro Alberto García, Ángel |
author_facet | Herrera-Leaño, Nancy Barahona-Correa, Julián E. Muñoz-Velandia, Oscar Fernández-Ávila, Daniel G. Mariño-Correa, Alejandro Alberto García, Ángel |
author_sort | Herrera-Leaño, Nancy |
collection | PubMed |
description | INTRODUCTION: Diuretic efficiency (DE) is an independent predictor of all-cause mortality in acute heart failure (HF) at long-term follow-up. The performance of DE in advanced HF and the outpatient scenario is unclear. METHODS: Survival function analysis on a retrospective cohort of patients with advanced HF followed at the outpatient clinic of Hospital Universitario San Ignacio (Bogotá, Colombia) between 2017 and 2021. DE was calculated as the average of total diuresis in milliliters divided by the dose of IV furosemide in milligrams for each 6-h session, considering all the sessions in which the patient received levosimendan and IV furosemide. We stratified DE in high or low using the median value of the cohort as the cutoff value. The primary outcome was a composite of all-cause mortality and HF hospitalizations during a 12-month follow-up. Kaplan–Meier curves and log-rank test were used to compare patients with high and low DE. RESULTS: In all, 41 patients (66.5 ± 13.2 years old, 75.6% men) were included in the study, with a median DE of 24.5 mL/mg. In total, 20 patients were categorized as low and 21 as high DE. The composite outcome occurred more often in the high DE group (13 versus 5, log-rank test p = 0.0385); the all-cause mortality rate was 29.2% and was more frequent in the high DE group (11 versus 1, log-rank test p = 0.0026). CONCLUSION: In patients with advanced HF on intermittent inotropic therapy, a high DE efficiency is associated with a higher risk of mortality or HF hospitalization in a 12-month follow-up period. |
format | Online Article Text |
id | pubmed-10331187 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-103311872023-07-11 Evaluation of diuretic efficiency of intravenous furosemide in patients with advanced heart failure in a heart failure clinic Herrera-Leaño, Nancy Barahona-Correa, Julián E. Muñoz-Velandia, Oscar Fernández-Ávila, Daniel G. Mariño-Correa, Alejandro Alberto García, Ángel Ther Adv Cardiovasc Dis Original Research INTRODUCTION: Diuretic efficiency (DE) is an independent predictor of all-cause mortality in acute heart failure (HF) at long-term follow-up. The performance of DE in advanced HF and the outpatient scenario is unclear. METHODS: Survival function analysis on a retrospective cohort of patients with advanced HF followed at the outpatient clinic of Hospital Universitario San Ignacio (Bogotá, Colombia) between 2017 and 2021. DE was calculated as the average of total diuresis in milliliters divided by the dose of IV furosemide in milligrams for each 6-h session, considering all the sessions in which the patient received levosimendan and IV furosemide. We stratified DE in high or low using the median value of the cohort as the cutoff value. The primary outcome was a composite of all-cause mortality and HF hospitalizations during a 12-month follow-up. Kaplan–Meier curves and log-rank test were used to compare patients with high and low DE. RESULTS: In all, 41 patients (66.5 ± 13.2 years old, 75.6% men) were included in the study, with a median DE of 24.5 mL/mg. In total, 20 patients were categorized as low and 21 as high DE. The composite outcome occurred more often in the high DE group (13 versus 5, log-rank test p = 0.0385); the all-cause mortality rate was 29.2% and was more frequent in the high DE group (11 versus 1, log-rank test p = 0.0026). CONCLUSION: In patients with advanced HF on intermittent inotropic therapy, a high DE efficiency is associated with a higher risk of mortality or HF hospitalization in a 12-month follow-up period. SAGE Publications 2023-07-07 /pmc/articles/PMC10331187/ /pubmed/37417658 http://dx.doi.org/10.1177/17539447231184984 Text en © The Author(s), 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Research Herrera-Leaño, Nancy Barahona-Correa, Julián E. Muñoz-Velandia, Oscar Fernández-Ávila, Daniel G. Mariño-Correa, Alejandro Alberto García, Ángel Evaluation of diuretic efficiency of intravenous furosemide in patients with advanced heart failure in a heart failure clinic |
title | Evaluation of diuretic efficiency of intravenous furosemide in patients with advanced heart failure in a heart failure clinic |
title_full | Evaluation of diuretic efficiency of intravenous furosemide in patients with advanced heart failure in a heart failure clinic |
title_fullStr | Evaluation of diuretic efficiency of intravenous furosemide in patients with advanced heart failure in a heart failure clinic |
title_full_unstemmed | Evaluation of diuretic efficiency of intravenous furosemide in patients with advanced heart failure in a heart failure clinic |
title_short | Evaluation of diuretic efficiency of intravenous furosemide in patients with advanced heart failure in a heart failure clinic |
title_sort | evaluation of diuretic efficiency of intravenous furosemide in patients with advanced heart failure in a heart failure clinic |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10331187/ https://www.ncbi.nlm.nih.gov/pubmed/37417658 http://dx.doi.org/10.1177/17539447231184984 |
work_keys_str_mv | AT herreraleanonancy evaluationofdiureticefficiencyofintravenousfurosemideinpatientswithadvancedheartfailureinaheartfailureclinic AT barahonacorreajuliane evaluationofdiureticefficiencyofintravenousfurosemideinpatientswithadvancedheartfailureinaheartfailureclinic AT munozvelandiaoscar evaluationofdiureticefficiencyofintravenousfurosemideinpatientswithadvancedheartfailureinaheartfailureclinic AT fernandezaviladanielg evaluationofdiureticefficiencyofintravenousfurosemideinpatientswithadvancedheartfailureinaheartfailureclinic AT marinocorreaalejandro evaluationofdiureticefficiencyofintravenousfurosemideinpatientswithadvancedheartfailureinaheartfailureclinic AT albertogarciaangel evaluationofdiureticefficiencyofintravenousfurosemideinpatientswithadvancedheartfailureinaheartfailureclinic |