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Formulation, optimization, in-vivo biodistribution studies and histopathological safety assessment of duloxetine HCl-loaded ultra-elastic nanovesicles for antidepressant effect after intranasal and transdermal delivery

Duloxetine hydrochloride (DUL) is a BCS class-II antidepressant drug, acting via serotonin and norepinephrine reuptake inhibition. Despite high oral absorption, DUL suffers limited bioavailability due to extensive gastric and first-pass metabolism. To improve DUL's bioavailability; DUL-loaded e...

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Detalles Bibliográficos
Autores principales:	Abd-Elal, Radwa M.A., Essawy, Aya M., Salem, Maha A., Elsayed, Mahitab, Khalil, Mona G., Abdelhakeem, Eman, Ali, Nouran A., Tawfik, Mai Ahmed
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10331411/ https://www.ncbi.nlm.nih.gov/pubmed/37434966 http://dx.doi.org/10.1016/j.ijpx.2023.100194

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