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Transforming growth factor-β1 and SMAD signalling pathway in the small airways of smokers and patients with COPD: potential role in driving fibrotic type-2 epithelial mesenchymal transition

BACKGROUND: COPD is a common disease characterized by respiratory airflow obstruction. TGF-β1 and SMAD pathway is believed to play a role in COPD pathogenesis by driving epithelial mesenchymal transition (EMT). METHODS: We investigated TGF-β1 signalling and pSmad2/3 and Smad7 activity in resected sm...

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Detalles Bibliográficos
Autores principales:	Brake, Samuel James, Lu, Wenying, Chia, Collin, Haug, Greg, Larby, Josie, Hardikar, Ashutosh, Singhera, Gurpreet K., Hackett, Tillie L., Eapen, Mathew Suji, Sohal, Sukhwinder Singh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10331458/ https://www.ncbi.nlm.nih.gov/pubmed/37435075 http://dx.doi.org/10.3389/fimmu.2023.1216506

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