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Identification of small molecules and related targets that modulate tau pathology in a seeded primary neuron model
Alzheimer’s disease (AD) is characterized by the presence of tau protein inclusions and amyloid beta (Aβ) plaques in the brain, with Aβ peptides generated by cleavage of the amyloid precursor protein (APP) by BACE1 and γ-secretase. We previously described a primary rat neuron assay in which tau incl...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10331484/ https://www.ncbi.nlm.nih.gov/pubmed/37269953 http://dx.doi.org/10.1016/j.jbc.2023.104876 |