The role of microglial LRRK2 kinase in manganese-induced inflammatory neurotoxicity via NLRP3 inflammasome and RAB10-mediated autophagy dysfunction

Chronic manganese (Mn) exposure can lead to manganism, a neurological disorder sharing common symptoms with Parkinson's disease (PD). Studies have shown that Mn can increase the expression and activity of leucine-rich repeat kinase 2 (LRRK2), leading to inflammation and toxicity in microglia. L...

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Detalles Bibliográficos
Autores principales: Pajarillo, Edward, Kim, Sanghoon, Digman, Alexis, Dutton, Matthew, Son, Deok-Soo, Aschner, Michael, Lee, Eunsook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10331485/
https://www.ncbi.nlm.nih.gov/pubmed/37269951
http://dx.doi.org/10.1016/j.jbc.2023.104879

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